CaMKipedia | Result

Graphics credits: COMPARTMENTS | More Info

Sequence Viewer

Gene

PHKG1

Synonyms

PHKG

Protein Name

Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform

UniProt ID

P00518

Ensembl Gene ID

9986.ENSOCUP00000011717

NCBI Gene ID

100009297

Molecular Weight

44,803

Protein Length

387

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 2phk)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

2.7.11.19; 2.7.11.1; 2.7.11.26 (BRENDA)

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

2 ATP + phosphorylase b = 2 ADP + phosphorylase a.; ATP + [tau protein] = ADP + [tau protein] phosphate.; ATP + a protein = ADP + a phosphoprotein.

Localization

N/A

Function

Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. In vitro, phosphorylates PYGM, TNNI3, MAPT/TAU, GAP43 and NRGN/RC3.

Gene Ontology

GO:0004689; GO:0005516; GO:0005524; GO:0005964; GO:0005978; GO:0050321; GO:0098723

Substrate	Organism	PSite	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
PYGM (P00489)	Oryctolagus cuniculus	S15	QEKRKQISVRGLAGV	-	0.3599	TP	certain	experimental	8 \|	7706257	-	-
MAPT * (P10636-8)	Homo sapiens	S237	RTPPKSPSSAKSRLQ	-	-	TP	certain	experimental	72 \| 107 \| 132 \| 135 \|	8999860	-	-
MAPT * (P10636-8)	Homo sapiens	S262	NVKSKIGSTENLKHQ	-	-	TP	certain	experimental	72 \| 107 \| 132 \| 135 \|	8999860	-	-
MAPT * (P10636-8)	Homo sapiens	S285	INKKLDLSNVQSKCG	-	-	TP	certain	experimental	72 \| 107 \| 132 \| 135 \|	8999860	-	-
MAPT * (P10636-8)	Homo sapiens	S305	KHVPGGGSVQIVYKP	-	-	TP	certain	experimental	72 \| 107 \| 132 \| 135 \|	8999860	-	-
MAPT (P10636-8)	Homo sapiens	S352	DFKDRVQSKIGSLDN	-	-	TP	certain	experimental	72 \| 107 \| 132 \| 135 \|	8999860	-	-
Nrgn * (Q04940)	Rattus norvegicus	S36	AAAKIQASFRGHMAR	-	0.5211	TP	certain	experimental	132 \| 72 \| 135 \| 16 \|	8454596	-	-
Gap43 * (P07936)	Rattus norvegicus	S41	AATKIQASFRGHITR	-	0.6712	TP	certain	experimental	132 \| 72 \| 135 \| 16 \|	8454596	-	-

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system TAS \| Reactome Pathway
R-HSA-168256	Immune System TAS \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins TAS \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling TAS \| Reactome Pathway

No KEGG pathways found

No NCI Nature pathways found