Protein Name
Calcium/calmodulin-dependent protein kinase type II subunit alpha
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
54,115
Protein Length
478
Protein Domain
3D Structure
(PDB ID : 1hkx)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
Catalytic Site
Catalytic Activity
ATP + a protein = ADP + a phosphoprotein.
Localization
Isoform Alpha KAP: Cytoplasm; Cell junction, synapse Cell junction, synapse, postsynaptic cell membrane, postsynaptic density Cell projection, dendritic spine Cell projection, dendrite Note=Postsynaptic lipid rafts.
Function
Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in synaptic plasticity, neurotransmitter release and long-term potentiation. Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (By similarity). Regulates dendritic spine development. Also regulates the migration of developing neurons (By similarity). Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (PubMed:23805378).
Gene Ontology
GO:0000082; GO:0002931; GO:0004674; GO:0004683; GO:0005516; GO:0005524; GO:0005634; GO:0005737; GO:0005739; GO:0005829; GO:0005954; GO:0006468; GO:0006816; GO:0009931; GO:0010666; GO:0014069; GO:0016020; GO:0016301; GO:0018105; GO:0030054; GO:0030424; GO:0030425; GO:0032794; GO:0032839; GO:0035235; GO:0035254; GO:0038166; GO:0042802; GO:0042803; GO:0043005; GO:0043025; GO:0043197; GO:0046777; GO:0046872; GO:0046928; GO:0048168; GO:0048813; GO:0051092; GO:0051928; GO:0060996; GO:0098685; GO:0098696; GO:0098970; GO:0098978; GO:0098989; GO:0099004; GO:0099148; GO:0099523; GO:0099524; GO:0099573; GO:0099634; GO:1902108; GO:1903076; GO:1990443; GO:2001222
