| Gene |
Grin2b
|
| Protein Name |
NMDE2_RAT |
| Organism |
Rattus norvegicus (Rat) |
| Alternative name(s) |
Glutamate receptor ionotropic, NMDA 2B (GluN2B) (Glutamate [NMDA] receptor subunit epsilon-2) (N-methyl D-aspartate receptor subtype 2B) (NMDAR2B) (NR2B) |
| Protein Family |
Glutamate-gated ion channel (TC 1.A.10.1) family |
| NCBI Gene ID |
24410
|
| UniProt ID |
Q00960
|
| Enzyme Class |
- |
| Molecular Weight |
166071 |
| Protein Length |
1482 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cell membrane |
| Function (UniProt annotation) |
Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:1350383, PubMed:19910922, PubMed:21677647, PubMed:24876489, PubMed:27135925, PubMed:27916457). Sensitivity to glutamate and channel kinetics depend on the subunit composition (Probable). In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death. Contributes to neural pattern formation in the developing brain. Plays a role in long-term depression (LTD) of hippocampus membrane currents and in synaptic plasticity (By similarity). |
| Gene Ontology |
GO:0001508; GO:0001662; GO:0001666; GO:0001975; GO:0004970; GO:0004972; GO:0005102; GO:0005149; GO:0005234; GO:0005622; GO:0005886; GO:0005887; GO:0007611; GO:0007613; GO:0007616; GO:0008013; GO:0008144; GO:0008270; GO:0008306; GO:0009612; GO:0009636; GO:0009743; GO:0009986; GO:0010042; GO:0010243; GO:0010350; GO:0010942; GO:0014049; GO:0014069; GO:0014070; GO:0014075; GO:0016595; GO:0017146; GO:0021766; GO:0021987; GO:0022849; GO:0030018; GO:0030054; GO:0031749; GO:0032026; GO:0033555; GO:0034097; GO:0035235; GO:0035255; GO:0042165; GO:0042220; GO:0042734; GO:0043005; GO:0043025; GO:0043083; GO:0043113; GO:0043195; GO:0043197; GO:0043408; GO:0045202; GO:0045471; GO:0046960; GO:0046982; GO:0048169; GO:0048511; GO:0050806; GO:0050839; GO:0051290; GO:0051592; GO:0051597; GO:0051602; GO:0051707; GO:0060079; GO:0060291; GO:0060416; GO:0060992; GO:0071230; GO:0071287; GO:0071359; GO:0071363; GO:0071386; GO:0071396; GO:0071407; GO:0097110; GO:0097440; GO:0097553; GO:0098686; GO:0098688; GO:0098839; GO:0098978; GO:0098989; GO:0099056; GO:0099061; GO:0099566; GO:0099583; GO:1904315; GO:1904322; GO:1904644; GO:2001056 |
