CaMKipedia | Result

Graphics credits: COMPARTMENTS | More Info

Sequence Viewer

Gene

Pim3

Synonyms

N/A

Protein Name

Serine/threonine-protein kinase pim-3

UniProt ID

P58750

Ensembl Gene ID

10090.ENSMUSP00000044603

NCBI Gene ID

223775

Molecular Weight

35,970

Protein Length

326

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : N/A)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

2.7.11.1 (BRENDA)

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

ATP + a protein = ADP + a phosphoprotein.

Localization

Cytoplasm

Function

Proto-oncogene with serine/threonine kinase activity that can prevent apoptosis and promote cell survival and protein translation. May contribute to tumorigenesis through: the delivery of survival signaling through phosphorylation of BAD which induces release of the anti-apoptotic protein Bcl-X(L), the regulation of cell cycle progression and protein synthesis and by regulation of MYC transcriptional activity. Additionally to this role on tumorigenesis, can also negatively regulate insulin secretion by inhibiting the activation of MAPK1/3 (ERK1/2), through SOCS6. Involved also in the control of energy metabolism and regulation of AMPK activity in modulating MYC and PPARGC1A protein levels and cell growth.

Gene Ontology

GO:0004674; GO:0005524; GO:0005737; GO:0005829; GO:0006468; GO:0006915; GO:0007049; GO:0007346; GO:0016572; GO:0043066; GO:0046777; GO:0061179

Substrate	Organism	PSite	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
Bad (Q61337)	Mus musculus	S155	GRELRRMSDEFEGSF	-	0.5533	TP	certain	experimental	72 \| 135 \| 133 \| 30 \| 73 \| 9 \| 55 \|	16403219	-	-
Bad (Q61337)	Mus musculus	S96	QGRAATNSHHGGAGA	-	0.8792	TP	certain	experimental	72 \| 133 \| 30 \|	16403219	-	-
Bad (Q61337)	Mus musculus	S112	ETRSRHSSYPAGTEE	-	0.8872	TP	certain	experimental	72 \| 133 \| 30 \| 55 \| 73 \|	16403219	-	-
Bad (Q61337)	Mus musculus	S136	PFRGRSRSAPPNLWA	-	0.6755	TP	certain	experimental	72 \| 133 \| 30 \| 55 \| 73 \|	16403219	-	-
Bad (Q61337)	Mus musculus	S170	KGLPRPKSAGTATQM	-	0.8313	TP	certain	experimental	72 \| 133 \| 30 \|	16403219	-	-
Bad (Q61337)	Mus musculus	T94	HQQGRAATNSHHGGA	-	0.8741	TP	certain	experimental	72 \| 133 \| 30 \|	16403219	-	-
Bad (Q61337)	Mus musculus	T173	PRPKSAGTATQMRQS	-	0.7982	TP	certain	experimental	72 \| 133 \| 30 \|	16403219	-	-

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system TAS \| Reactome Pathway
R-HSA-168256	Immune System TAS \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins TAS \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling TAS \| Reactome Pathway

No KEGG pathways found

No NCI Nature pathways found