CaMKinet | Result

Sequence Viewer

Parameter	Value
Gene	Bad
Protein Name	BAD_MOUSE
Organism	Mus musculus (Mouse)
Alternative name(s)	Bcl2-associated agonist of cell death (BAD) (Bcl-2-binding component 6) (Bcl-xL/Bcl-2-associated death promoter) (Bcl2 antagonist of cell death)
Protein Family	Bcl-2 family
NCBI Gene ID	12015
UniProt ID	Q61337
Enzyme Class	-
Molecular Weight	22080
Protein Length	204
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	Mitochondrion outer membrane. Cytoplasm
Function (UniProt annotation)	Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2. Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.
Gene Ontology	GO:0001836; GO:0005543; GO:0005737; GO:0005739; GO:0005741; GO:0005829; GO:0006007; GO:0006915; GO:0006919; GO:0007283; GO:0008283; GO:0008289; GO:0008625; GO:0008630; GO:0008656; GO:0009749; GO:0010918; GO:0019050; GO:0019221; GO:0019901; GO:0019903; GO:0021987; GO:0030346; GO:0032024; GO:0032355; GO:0032570; GO:0033133; GO:0033574; GO:0034201; GO:0035774; GO:0042542; GO:0042593; GO:0042981; GO:0043065; GO:0043200; GO:0043280; GO:0043281; GO:0043422; GO:0044342; GO:0045471; GO:0045579; GO:0045582; GO:0045862; GO:0046031; GO:0046034; GO:0046902; GO:0046931; GO:0046982; GO:0050679; GO:0051384; GO:0051592; GO:0060139; GO:0060154; GO:0071247; GO:0071260; GO:0071310; GO:0071316; GO:0071396; GO:0071456; GO:0071889; GO:0090200; GO:0097190; GO:0097191; GO:0097192; GO:0097193; GO:0097202; GO:1901216; GO:1902220; GO:1904710; GO:2000078

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
PIM2* (Q9P1W9)	Homo sapiens	S136	PFRGRSRSAPPNLWA	N/A	0.6755	U	unlikely	experimental	214 \|	16403219	-	In vivo
PIM2* (Q9P1W9)	Homo sapiens	S155	GRELRRMSDEFEGSF	N/A	0.5533	U	unlikely	experimental	214 \|	16403219	-	In vivo
PIM1 (P11309)	Homo sapiens	S112	ETRSRHSSYPAGTEE	N/A	0.8872	TP	certain	experimental	72 \| 135 \| 133 \| 30 \| 73 \| 9 \|	16403219	-	-
PIM2 (Q9P1W9)	Homo sapiens	S112	ETRSRHSSYPAGTEE	N/A	0.8872	TP	certain	experimental	72 \| 135 \| 133 \| 30 \| 73 \| 9 \|	16403219	-	-
PIM1 (P11309)	Homo sapiens	S136	PFRGRSRSAPPNLWA	N/A	0.6755	TP	certain	experimental	72 \| 135 \| 133 \| 30 \| 73 \| 9 \|	16403219	-	-
PIM1 (P11309)	Homo sapiens	S155	GRELRRMSDEFEGSF	N/A	0.5533	TP	certain	experimental	72 \| 135 \| 133 \| 30 \| 73 \| 9 \|	16403219	-	-
Pim3 (P58750)	Mus musculus	S155	GRELRRMSDEFEGSF	N/A	0.5533	TP	certain	experimental	72 \| 135 \| 133 \| 30 \| 73 \| 9 \| 55 \|	16403219	-	-
CAMK2G (Q13555)	Homo sapiens	S170	KGLPRPKSAGTATQM	N/A	0.8313	TP	certain	experimental	72 \| 55 \| 9 \| 73 \|	22103330	-	-
Pim3 (P58750)	Mus musculus	S96	QGRAATNSHHGGAGA	N/A	0.8792	TP	certain	experimental	72 \| 133 \| 30 \|	16403219	-	-
Pim3 (P58750)	Mus musculus	S112	ETRSRHSSYPAGTEE	N/A	0.8872	TP	certain	experimental	72 \| 133 \| 30 \| 55 \| 73 \|	16403219	-	-
Pim3 (P58750)	Mus musculus	S136	PFRGRSRSAPPNLWA	N/A	0.6755	TP	certain	experimental	72 \| 133 \| 30 \| 55 \| 73 \|	16403219	-	-
Pim3 (P58750)	Mus musculus	S170	KGLPRPKSAGTATQM	N/A	0.8313	TP	certain	experimental	72 \| 133 \| 30 \|	16403219	-	-
Pim3 (P58750)	Mus musculus	T94	HQQGRAATNSHHGGA	N/A	0.8741	TP	certain	experimental	72 \| 133 \| 30 \|	16403219	-	-
Pim3 (P58750)	Mus musculus	T173	PRPKSAGTATQMRQS	N/A	0.7982	TP	certain	experimental	72 \| 133 \| 30 \|	16403219	-	-
CHEK1 (O14757)	Homo sapiens	S155	GRELRRMSDEFEGSF	N/A	0.5533	-	-	-	-	-	-	-
CHEK1 (O14757)	Homo sapiens	S170	KGLPRPKSAGTATQM	N/A	0.8313	-	-	-	-	-	-	-
RPS6KA5 (O75582)	Homo sapiens	S155	GRELRRMSDEFEGSF	N/A	0.5533	-	-	-	-	-	-	In vitro
RPS6KA1 (Q15418)	Homo sapiens	S112	ETRSRHSSYPAGTEE	N/A	0.8872	-	-	-	-	-	-	In vitro and in vivo
RPS6KA1 (Q15418)	Homo sapiens	S136	PFRGRSRSAPPNLWA	N/A	0.6755	-	-	-	-	-	-	In vitro
RPS6KA1 (Q15418)	Homo sapiens	S155	GRELRRMSDEFEGSF	N/A	0.5533	-	-	-	-	-	-	In vitro
PIM3 (Q86V86)	Homo sapiens	S112	ETRSRHSSYPAGTEE	N/A	0.8872	-	-	-	-	-	-	In vivo
PIM3 (Q86V86)	Homo sapiens	S136	PFRGRSRSAPPNLWA	N/A	0.6755	-	-	-	-	-	-	In vivo
PIM3 (Q86V86)	Homo sapiens	S155	GRELRRMSDEFEGSF	N/A	0.5533	-	-	-	-	-	-	In vivo

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
mmu04012	ErbB signaling pathway
mmu04210	Apoptosis
mmu04370	VEGF signaling pathway
mmu04510	Focal adhesion
mmu04722	Neurotrophin signaling pathway
mmu04910	Insulin signaling pathway
mmu05010	Alzheimer's disease
mmu05014	Amyotrophic lateral sclerosis (ALS)
mmu05145	Toxoplasmosis
mmu05152	Tuberculosis
mmu05160	Hepatitis C
mmu05200	Pathways in cancer
mmu05210	Colorectal cancer
mmu05212	Pancreatic cancer
mmu05213	Endometrial cancer
mmu05215	Prostate cancer
mmu05218	Melanoma
mmu05220	Chronic myeloid leukemia
mmu05221	Acute myeloid leukemia
mmu05223	Non-small cell lung cancer

No NCI Nature pathways found