CaMKipedia | Result

Graphics credits: COMPARTMENTS | More Info

Sequence Viewer

Gene

Camkk1

Synonyms

N/A

Protein Name

Calcium/calmodulin-dependent protein kinase kinase 1

UniProt ID

P97756

Ensembl Gene ID

10116.ENSRNOP00000025009

NCBI Gene ID

60341

Molecular Weight

55,908

Protein Length

505

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 1CKK)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

2.7.11.17 (BRENDA)

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

ATP + a protein = ADP + a phosphoprotein.

Localization

Cytoplasm. Nucleus.

Function

Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death.

Gene Ontology

GO:0004674; GO:0004683; GO:0005516; GO:0005524; GO:0005634; GO:0005737; GO:0006468; GO:0032147; GO:0035556; GO:0045860

Substrate	Organism	PSite	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
Camk4 (P13234)	Rattus norvegicus	T196	EHQVLMKTVCGTPGY	-	0.0888	TP	certain	experimental	8 \| 273 \|	9163534	-	-
Camk4 (P13234)	Rattus norvegicus	T200	LMKTVCGTPGYCAPE	-	0.0835	TP	certain	experimental	8 \| 273 \|	9163534	-	-

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system TAS \| Reactome Pathway
R-HSA-168256	Immune System TAS \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins TAS \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling TAS \| Reactome Pathway

No KEGG pathways found

No NCI Nature pathways found