CaMKinet | Result

Sequence Viewer

Parameter	Value
Gene	Camk4
Protein Name	KCC4_RAT
Organism	Rattus norvegicus (Rat)
Alternative name(s)	Calcium/calmodulin-dependent protein kinase type IV (CaMK IV) (EC 2.7.11.17) (CaM kinase-GR) (Calspermin)
Protein Family	Protein kinase superfamily
NCBI Gene ID	25050
UniProt ID	P13234
Enzyme Class	2.7.11.17
Molecular Weight	53151
Protein Length	474
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	ATP + a protein = ADP + a phosphoprotein.
Localization	Cytoplasm. Nucleus. Note=Localized in hippocampal neuron nuclei. In spermatids, associated with chromatin and nuclear matrix.
Function (UniProt annotation)	Isoform 1: Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18 (By similarity).
Gene Ontology	GO:0001650; GO:0002250; GO:0004683; GO:0005516; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006468; GO:0006954; GO:0007616; GO:0009931; GO:0018105; GO:0035556; GO:0043011; GO:0045893; GO:0098794; GO:0098978

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
Camkk1 (P97756)	Rattus norvegicus	T196	EHQVLMKTVCGTPGY	N/A	0.0888	TP	certain	experimental	8 \| 273 \|	9163534	-	-
Camkk1 (P97756)	Rattus norvegicus	T200	LMKTVCGTPGYCAPE	N/A	0.0835	TP	certain	experimental	8 \| 273 \|	9163534	-	-
CAMK4 (Q16566)	Homo sapiens	S437	DQEMKRNSEETLKSV	N/A	0.9519	-	-	-	-	8340352	Non high throughput (8340352)	-
CAMKK1 (Q8N5S9)	Homo sapiens	T196	EHQVLMKTVCGTPGY	N/A	0.0888	-	-	-	-	15262966, 7615569, 9163534	Non high throughput (15262966, 7615569, 9163534)	-
CAMKK1 (Q8N5S9)	Homo sapiens	T200	LMKTVCGTPGYCAPE	N/A	0.0835	-	-	-	-	9163534	Non high throughput (9163534)	-

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
rno04020	Calcium signaling pathway
rno04380	Osteoclast differentiation
rno04720	Long-term potentiation
rno04722	Neurotrophin signaling pathway
rno04725	Cholinergic synapse

No NCI Nature pathways found