CaMKipedia | Result

Graphics credits: COMPARTMENTS | More Info

Sequence Viewer

Gene

PNCK

Synonyms

N/A

Protein Name

Calcium/calmodulin-dependent protein kinase type 1B

UniProt ID

Q6P2M8

Ensembl Gene ID

9606.ENSP00000405950

NCBI Gene ID

139728

Molecular Weight

38,500

Protein Length

343

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : N/A)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

2.7.11.17 (BRENDA)

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

ATP + a protein = ADP + a phosphoprotein.

Localization

Cytoplasm Nucleus

Function

Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates CREB1 and SYN1/synapsin I. Phosphorylates and activates CAMK1 (By similarity).

Gene Ontology

GO:0004683; GO:0005516; GO:0005524; GO:0005634; GO:0005737

Substrate	Organism	PSite	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
EIF4G3 (O43432)	Homo sapiens	S1156	NTFMRGGSSKDLLDN	0.511	0.7547	TP	certain	experimental	72 \| 73 \| 8 \| 55 \|	22514323	-	-
HSP90AA1 (P07900)	Homo sapiens	S391	FIRGVVDSEDLPLNI	0.775	0.1184	TP	certain	experimental	205 \| 31 \| 36 \|	21325639	-	-
HSP90AB1 (P08238)	Homo sapiens	T89	RTLTLVDTGIGMTKA	0.689	0.3149	TP	certain	experimental	205 \| 31 \| 36 \|	21325639	-	-
HSP90AB1 (P08238)	Homo sapiens	T616	QALRDNSTMGYMMAK	0.493	0.4017	TP	certain	experimental	205 \| 31 \| 36 \|	21325639	-	-
HSP90AA1 (P07900)	Homo sapiens	T624	QALRDNSTMGYMAAK	0.447	0.3983	-	-	-	-	-	-	In vitro and in vivo

Kinase

Substrate

Interactor

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system TAS \| Reactome Pathway
R-HSA-168256	Immune System TAS \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins TAS \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling TAS \| Reactome Pathway

No KEGG pathways found

No NCI Nature pathways found