Gene
Synonyms
C14orf20 STK22E TSSK5
Protein Name
Testis-specific serine/threonine-protein kinase 4
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
37,454
Protein Length
328
Protein Domain
3D Structure
(PDB ID : N/A)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
Catalytic Site
Catalytic Activity
ATP + a protein = ADP + a phosphoprotein.
Localization
Cytoplasmic vesicle, secretory vesicle, acrosome Cell projection, cilium, flagellum Note=In spermatozoa, present in the sperm head and in the flagellum.
Function
Serine/threonine kinase which is involved in male germ cell development and in mature sperm function (By similarity). May be involved in the Cre/Creb signaling pathway (By similarity). Phosphorylates CREB1 on 'Ser-133' in vitro and can stimulate Cre/Creb pathway in cells (PubMed:15964553). Phosphorylates CREM on 'Ser-116' in vitro (By similarity). Phosphorylates ODF2 on 'Ser-95' (By similarity).
Gene Ontology
GO:0000287; GO:0001669; GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0006468; GO:0007275; GO:0007283; GO:0030154; GO:0031514; GO:0032793; GO:0035556
