CaMKinet | Result

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Sequence Viewer

Parameter	Value
Gene	CREB1
Protein Name	CREB1_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Cyclic AMP-responsive element-binding protein 1 (CREB-1) (cAMP-responsive element-binding protein 1)
Protein Family	BZIP family
NCBI Gene ID	1385
UniProt ID	P16220
Enzyme Class	-
Molecular Weight	36688
Protein Length	341
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	Nucleus
Function (UniProt annotation)	Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells.
Gene Ontology	GO:0000978; GO:0000980; GO:0000981; GO:0001077; GO:0001102; GO:0001225; GO:0001228; GO:0001666; GO:0003700; GO:0003705; GO:0003712; GO:0005634; GO:0005654; GO:0005667; GO:0005719; GO:0005759; GO:0006366; GO:0006468; GO:0007165; GO:0007179; GO:0007409; GO:0007568; GO:0007595; GO:0007613; GO:0007623; GO:0008361; GO:0008542; GO:0010033; GO:0010944; GO:0014823; GO:0016032; GO:0019899; GO:0021983; GO:0030424; GO:0030544; GO:0032916; GO:0033363; GO:0033762; GO:0034670; GO:0035035; GO:0035094; GO:0035497; GO:0035729; GO:0036120; GO:0040018; GO:0042752; GO:0042802; GO:0043065; GO:0045600; GO:0045672; GO:0045893; GO:0045899; GO:0045944; GO:0046887; GO:0046889; GO:0048145; GO:0050821; GO:0055025; GO:0060251; GO:0060430; GO:0060509; GO:0071294; GO:0071300; GO:0071398; GO:1900273; GO:1901215; GO:1902065; GO:1990090; GO:1990314; GO:1990589; GO:1990763; GO:1990830

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
MAPKAPK2 (P49139)	Oryctolagus cuniculus	S133	EILSRRPSYRKILND	N/A	0.5055	TP	likely	experimental	148 \| 55 \|	8887554	-	-
TSSK4* (Q6SA08)	Homo sapiens	S133	EILSRRPSYRKILND	N/A	0.5055	TP	certain	experimental	66 \| 72 \| 40 \| 9 \|	15964553	-	-
CAMK1D (Q8IU85)	Homo sapiens	S133	EILSRRPSYRKILND	N/A	0.5055	TP	certain	experimental	9 \| 72 \|	11050006	-	-
RPS6KA4 (O75676)	Homo sapiens	S133	EILSRRPSYRKILND	N/A	0.5055	-	-	-	-	-	-	In vivo
PRKD1 (Q15139)	Homo sapiens	S98	KDLKRLFSGTQISTI	N/A	0.4256	TP	certain	experimental	62 \| 72 \| 55 \|	17389598	-	-
PRKD1 (Q15139)	Homo sapiens	S133	EILSRRPSYRKILND	N/A	0.5055	TP	certain	experimental	62 \| 72 \| 55 \| 73 \| 23 \|	17389598	-	-
CAMK4 (Q16566)	Homo sapiens	S133	EILSRRPSYRKILND	N/A	0.5055	TP	certain	experimental	72 \| 73 \| 107 \| 8 \|	7958915	-	-
RPS6KA5 (O75582)	Homo sapiens	S133	EILSRRPSYRKILND	N/A	0.5055	-	-	-	-	-	-	In vitro and in vivo
MAPKAPK2 (P49137)	Homo sapiens	S133	EILSRRPSYRKILND	N/A	0.5055	-	-	-	-	8887554	Non high throughput (8887554)	In vitro and in vivo
RPS6KA3 (P51812)	Homo sapiens	S133	EILSRRPSYRKILND	N/A	0.5055	-	-	-	-	11698596	Non high throughput (11698596)	In vivo
RPS6KA2 (Q15349)	Homo sapiens	S133	EILSRRPSYRKILND	N/A	0.5055	-	-	-	-	11698596	Non high throughput (11698596)	In vivo
RPS6KA1 (Q15418)	Homo sapiens	S133	EILSRRPSYRKILND	N/A	0.5055	-	-	-	-	-	-	In vitro and in vivo
CAMK2D (Q13557)	Homo sapiens	S133	EILSRRPSYRKILND	N/A	0.5055	-	-	-	-	-	-	-
CAMK2D (Q13557)	Homo sapiens	S142	RKILNDLSSDAPGVP	N/A	0.5807	-	-	-	-	-	-	-
CAMK1 (Q14012)	Homo sapiens	S133	EILSRRPSYRKILND	N/A	0.5055	-	-	-	-	-	-	-
CAMK1G (Q96NX5)	Homo sapiens	S133	EILSRRPSYRKILND	N/A	0.5055	-	-	-	-	-	-	-
CAMK2A (Q9UQM7)	Homo sapiens	S142	RKILNDLSSDAPGVP	N/A	0.5807	-	-	-	-	-	-	-
CAMK2A (Q9UQM7)	Homo sapiens	S133	EILSRRPSYRKILND	N/A	0.5055	-	-	-	-	-	-	-
CAMK2B (Q13554)	Homo sapiens	S133	EILSRRPSYRKILND	N/A	0.5055	-	-	-	-	-	-	-
CAMK2G (Q13555)	Homo sapiens	S133	EILSRRPSYRKILND	N/A	0.5055	-	-	-	-	-	-	-
CAMK2B (Q13554)	Homo sapiens	S142	RKILNDLSSDAPGVP	N/A	0.5807	-	-	-	-	-	-	-
CAMK2G (Q13555)	Homo sapiens	S142	RKILNDLSSDAPGVP	N/A	0.5807	-	-	-	-	-	-	-

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
hsa04380	Osteoclast differentiation
hsa04612	Antigen processing and presentation
hsa04725	Cholinergic synapse
hsa04916	Melanogenesis
hsa04962	Vasopressin-regulated water reabsorption
hsa05016	Huntington's disease
hsa05152	Tuberculosis
hsa05215	Prostate cancer

NCI Nature PID Pathways

Pathway ID	Pathway Name
hif1_tfpathway	HIF-1-alpha transcription factor network
hnf3bpathway	FOXA2 and FOXA3 transcription factor networks
lpa4_pathway	LPA4-mediated signaling events
lymphangiogenesis_pathway	VEGFR3 signaling in lymphatic endothelium
mapktrkpathway	Trk receptor signaling mediated by the MAPK pathway
p38_mk2pathway	p38 signaling mediated by MAPKAP kinases
p38alphabetadownstreampathway	Signaling mediated by p38-alpha and p38-beta
pi3kplctrkpathway	Trk receptor signaling mediated by PI3K and PLC-gamma
ret_pathway	Signaling events regulated by Ret tyrosine kinase
smad2_3nuclearpathway	Regulation of nuclear SMAD2/3 signaling