Protein Name
MAP/microtubule affinity-regulating kinase 3
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
88,751
Protein Length
797
Protein Domain
3D Structure
(PDB ID : N/A)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
Catalytic Site
Catalytic Activity
ATP + a protein = ADP + a phosphoprotein.
Localization
Cell membrane Peripheral membrane protein Cell projection, dendrite Cytoplasm
Function
Serine/threonine-protein kinase. Involved in the specific phosphorylation of microtubule-associated proteins for MAPT/TAU, MAP2 and MAP4. Phosphorylates CDC25C. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1.
Gene Ontology
GO:0000226; GO:0004674; GO:0005524; GO:0005737; GO:0005886; GO:0006468; GO:0018105; GO:0030010; GO:0030425; GO:0032092; GO:0035331; GO:0035556; GO:0036289; GO:0050321
