CaMKinet | Result

Sequence Viewer

Parameter	Value
Gene	CDC25C
Protein Name	MPIP3_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	M-phase inducer phosphatase 3 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25C)
Protein Family	MPI phosphatase family
NCBI Gene ID	995
UniProt ID	P30307
Enzyme Class	3.1.3.48
Molecular Weight	53365
Protein Length	473
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
Localization	Nucleus
Function (UniProt annotation)	Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. When phosphorylated, highly effective in activating G2 cells into prophase. Directly dephosphorylates CDK1 and activates its kinase activity.
Gene Ontology	GO:0000079; GO:0000086; GO:0004721; GO:0004725; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006977; GO:0007088; GO:0007283; GO:0008283; GO:0010971; GO:0016032; GO:0016607; GO:0019901; GO:0045931; GO:0048471; GO:0050699; GO:0051301; GO:0110032

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
Mark3 (Q8VHF0)	Rattus norvegicus	S216	SGLYRSPSMPENLNR	0.868	0.6227	TP	certain	experimental	72 \| 9 \| 135 \| 73 \| 23 \| 20 \|	9543386	-	-
BRSK1 (Q8TDC3-2)	Homo sapiens	S216	SGLYRSPSMPENLNR	0.868	0.6227	TP	certain	experimental	72 \| 9 \| 73 \| 55 \|	15150265	-	-
MARK3 (P27448)	Homo sapiens	S216	SGLYRSPSMPENLNR	0.868	0.6227	TP	certain	experimental	72 \| 9 \| 137 \| 135 \| 55 \| 73 \| 23 \|	9543386	-	-
CHEK1 (O14757)	Homo sapiens	S216	SGLYRSPSMPENLNR	0.868	0.6227	-	-	-	-	-	-	In vitro
CHEK2 (O96017)	Homo sapiens	S216	SGLYRSPSMPENLNR	0.868	0.6227	-	-	-	-	10744722, 9836640	Non high throughput (10744722, 9836640)	In vitro
MAPKAPK2 (P49137)	Homo sapiens	S216	SGLYRSPSMPENLNR	0.868	0.6227	-	-	-	-	-	-	In vitro
BRSK1 (Q8TDC3)	Homo sapiens	S216	SGLYRSPSMPENLNR	0.868	0.6227	-	-	-	-	9543386	Non high throughput (9543386)	-
RPS6KA1 (Q15418)	Homo sapiens	S247	KVKKKYFSGQGKLRK	0.394	0.2436	-	-	-	-	-	-	in-vitro

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
hsa04110	Cell cycle
hsa04114	Oocyte meiosis
hsa04914	Progesterone-mediated oocyte maturation

No NCI Nature pathways found