| Gene |
Ryr2
|
| Protein Name |
RYR2_RAT |
| Organism |
Rattus norvegicus (Rat) |
| Alternative name(s) |
Ryanodine receptor 2 (RYR-2) (RyR2) (Cardiac muscle ryanodine receptor) (Cardiac muscle ryanodine receptor-calcium release channel) (Type 2 ryanodine receptor) |
| Protein Family |
Ryanodine receptor (TC 1.A.3.1) family |
| NCBI Gene ID |
689560
|
| UniProt ID |
B0LPN4
|
| Enzyme Class |
- |
| Molecular Weight |
562955 |
| Protein Length |
4953 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Sarcoplasmic reticulum membrane |
| Function (UniProt annotation) |
Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development (By similarity). |
| Gene Ontology |
GO:0003143; GO:0005219; GO:0005262; GO:0005509; GO:0005516; GO:0005635; GO:0005737; GO:0005783; GO:0005790; GO:0005886; GO:0006816; GO:0006874; GO:0007584; GO:0015278; GO:0016529; GO:0019722; GO:0030018; GO:0030659; GO:0031234; GO:0031672; GO:0032026; GO:0032991; GO:0033017; GO:0034220; GO:0034704; GO:0042383; GO:0042493; GO:0043005; GO:0048763; GO:0051209; GO:0051480; GO:0051481; GO:0051592; GO:0070296; GO:0070588; GO:0071313; GO:0071421; GO:0097110 |
