| Gene |
TP53
|
| Protein Name |
K7PPA8_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Cellular tumor antigen p53 |
| Protein Family |
P53 family |
| NCBI Gene ID |
7157
|
| UniProt ID |
K7PPA8
|
| Enzyme Class |
- |
| Molecular Weight |
43653 |
| Protein Length |
393 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cytoplasm |
| Function (UniProt annotation) |
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. |
| Gene Ontology |
GO:0003700; GO:0005654; GO:0005737; GO:0006915; GO:0007049; GO:0044212; GO:0046872; GO:0051262 |
