CaMKinet | Result

Sequence Viewer

Parameter	Value
Gene	EEF2K
Protein Name	EF2K_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Eukaryotic elongation factor 2 kinase (eEF-2 kinase) (eEF-2K) (EC 2.7.11.20) (Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase)
Protein Family	Protein kinase superfamily
NCBI Gene ID	29904
UniProt ID	O00418
Enzyme Class	2.7.11.20
Molecular Weight	82144
Protein Length	725
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	ATP + [elongation factor 2] = ADP + [elongation factor 2] phosphate.
Localization	N/A
Function (UniProt annotation)	Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced.
Gene Ontology	GO:0002931; GO:0004672; GO:0004686; GO:0005509; GO:0005516; GO:0005524; GO:0005737; GO:0005829; GO:0006414; GO:0008135; GO:0014069; GO:0031952; GO:0032869; GO:0043066; GO:0043197; GO:0045807; GO:0046777; GO:0051965; GO:0061003; GO:0071277; GO:0071320; GO:0071454; GO:1990416; GO:1990637

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
MAPKAPK2 (P49137)	Homo sapiens	S377	PPLLRPLSENSGDEN	0.736	0.8623	TP	certain	experimental	135 \| 133 \| 73 \| 55 \|	12171600	Non high throughput (12171600)	In vivo
PRKAA1 (Q13131)	Homo sapiens	S398	DSLPSSPSSATPHSQ	0.546	0.725	TP	certain	experimental	72 \| 73 \| 55 \| 214 \| 8 \| 107 \|	14709557	-	In vitro and in vivo
RPS6KA1 (Q15418)	Homo sapiens	S366	SPQVRTLSGSRPPLL	0.742	0.6322	-	-	-	-	-	-	In vitro and in vivo
PRKAA2 (P54646)	Homo sapiens	S398	DSLPSSPSSATPHSQ	0.546	0.725	-	-	-	-	-	-	in-vivo
PRKAA2 (P54646)	Homo sapiens	S366	SPQVRTLSGSRPPLL	0.742	0.6322	-	-	-	-	-	-	-
PRKAA2 (P54646)	Homo sapiens	S78	SSGSPANSFHFKEAW	0.374	0.374	-	-	-	-	-	-	-
PRKAA1 (Q13131)	Homo sapiens	S366	SPQVRTLSGSRPPLL	0.742	0.6322	-	-	-	-	-	-	-
PRKAA1 (Q13131)	Homo sapiens	S78	SSGSPANSFHFKEAW	0.374	0.374	-	-	-	-	-	-	-
MAPKAPK3 (Q16644)	Homo sapiens	S377	PPLLRPLSENSGDEN	0.736	0.8623	-	-	-	-	-	-	-
MAPKAPK5 (Q8IW41)	Homo sapiens	S377	PPLLRPLSENSGDEN	0.736	0.8623	-	-	-	-	-	-	-

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

No KEGG pathways found

NCI Nature PID Pathways

Pathway ID	Pathway Name
p38gammadeltapathway	Signaling mediated by p38-gamma and p38-delta