| Gene |
ACACB
|
| Protein Name |
ACACB_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Acetyl-CoA carboxylase 2 (EC 6.4.1.2) (ACC-beta) [Includes: Biotin carboxylase (EC 6.3.4.14)] |
| Protein Family |
N/A |
| NCBI Gene ID |
32
|
| UniProt ID |
O00763
|
| Enzyme Class |
6.4.1.2; 6.3.4.14 |
| Molecular Weight |
276541 |
| Protein Length |
2458 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
ATP + acetyl-CoA + HCO(3)(-) = ADP + phosphate + malonyl-CoA. |
| Localization |
Mitochondrion Endomembrane system. Note=May associate with membranes. |
| Function (UniProt annotation) |
Catalyzes the ATP-dependent carboxylation of acetyl-CoA to malonyl-CoA. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. Involved in inhibition of fatty acid and glucose oxidation and enhancement of fat storage (By similarity). May play a role in regulation of mitochondrial fatty acid oxidation through malonyl-CoA-dependent inhibition of carnitine palmitoyltransferase 1 (By similarity). |
| Gene Ontology |
GO:0003989; GO:0004075; GO:0005524; GO:0005634; GO:0005739; GO:0005741; GO:0005829; GO:0006084; GO:0006633; GO:0006853; GO:0009374; GO:0010629; GO:0010884; GO:0010906; GO:0012505; GO:0014070; GO:0031325; GO:0031667; GO:0031999; GO:0042493; GO:0042802; GO:0043086; GO:0045540; GO:0046872; GO:0051289; GO:0060421; GO:0097009; GO:2001295 |
