| Gene |
HSPB6
|
| Protein Name |
HSPB6_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Heat shock protein beta-6 (HspB6) (Heat shock 20 kDa-like protein p20) |
| Protein Family |
Small heat shock protein (HSP20) family |
| NCBI Gene ID |
126393
|
| UniProt ID |
O14558
|
| Enzyme Class |
- |
| Molecular Weight |
17136 |
| Protein Length |
160 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cytoplasm |
| Function (UniProt annotation) |
Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state. Seems to have versatile functions in various biological processes. Plays a role in regulating muscle function such as smooth muscle vasorelaxation and cardiac myocyte contractility. May regulate myocardial angiogenesis implicating KDR. Overexpression mediates cardioprotection and angiogenesis after induced damage. Stabilizes monomeric YWHAZ thereby supporting YWHAZ chaperone-like activity. |
| Gene Ontology |
GO:0005212; GO:0005576; GO:0005634; GO:0005737; GO:0006937; GO:0010667; GO:0042803; GO:0045766; GO:0051082; GO:0051087; GO:0061077 |
