| Gene |
CASK
|
| Protein Name |
CSKP_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Peripheral plasma membrane protein CASK (hCASK) (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase) (Protein lin-2 homolog) |
| Protein Family |
Protein kinase superfamily |
| NCBI Gene ID |
8573
|
| UniProt ID |
O14936
|
| Enzyme Class |
2.7.11.1 |
| Molecular Weight |
105123 |
| Protein Length |
926 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
ATP + a protein = ADP + a phosphoprotein. |
| Localization |
Nucleus |
| Function (UniProt annotation) |
Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1. |
| Gene Ontology |
GO:0001953; GO:0004385; GO:0004674; GO:0005516; GO:0005524; GO:0005604; GO:0005652; GO:0005730; GO:0005737; GO:0005829; GO:0005886; GO:0005911; GO:0005925; GO:0007155; GO:0007269; GO:0010839; GO:0015629; GO:0016323; GO:0016363; GO:0031982; GO:0042043; GO:0042734; GO:0045944; GO:0060170; GO:0061045; GO:0070509; GO:0090280; GO:0090288; GO:0098685; GO:2000300 |
