CaMKipedia | Result

Graphics credits: COMPARTMENTS | More Info

Sequence Viewer

Gene

CASK

Synonyms

LIN2

Protein Name

Peripheral plasma membrane protein CASK

UniProt ID

O14936

Ensembl Gene ID

9606.ENSP00000367408

NCBI Gene ID

8573

Molecular Weight

1,05,123

Protein Length

926

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 3c0g)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

2.7.11.1 (BRENDA)

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

ATP + a protein = ADP + a phosphoprotein.

Localization

Nucleus Cytoplasm Cell membrane Peripheral membrane protein

Function

Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1.

Gene Ontology

GO:0001953; GO:0004385; GO:0004674; GO:0005516; GO:0005524; GO:0005604; GO:0005652; GO:0005730; GO:0005737; GO:0005829; GO:0005886; GO:0005911; GO:0005925; GO:0007155; GO:0007269; GO:0010839; GO:0015629; GO:0016323; GO:0016363; GO:0031982; GO:0042043; GO:0042734; GO:0045944; GO:0060170; GO:0061045; GO:0070509; GO:0090280; GO:0090288; GO:0098685; GO:2000300

Gene Ontology

Substrate	Organism	PSite	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
CASK * (O14936)	Homo sapiens	S151	PHCVLLASKENSAPV	0.185	0.1852	U	likely	experimental	72 \| 31 \|	18423203	-	-
CASK (O14936)	Homo sapiens	S155	LLASKENSAPVKLGG	0.659	0.0749	U	likely	experimental	72 \| 31 \|	18423203	-	-
Nrxn1 * (Q63372-1)	Rattus norvegicus	S428	TGYTQEDYTMLGSDD	-	-	U	likely	experimental	72 \| 73 \| 55 \| 31 \|	18423203	-	-
NRXN1 (P58400)	Homo sapiens	S455	VKEKQPSSAKSSNKN	-	0.7331	-	-	-	-	-	-	In vitro
NRXN1 (P58400)	Homo sapiens	S458	KQPSSAKSSNKNKKN	-	0.8313	-	-	-	-	-	-	In vitro
NRXN1 (P58400-1)	Homo sapiens	S424	MYKYRNRDEGSYHVD	-	-	-	-	-	-	-	-	In vitro
NRXN1 (P58400-1)	Homo sapiens	S428	KQPSSAKSSNKNKKN	-	-	-	-	-	-	-	-	in-vitro
NRXN1 (P58400-1)	Homo sapiens	S425	VKEKQPSSAKSSNKN	-	-	-	-	-	-	-	-	in-vitro

Kinase

Substrate

Interactor

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system TAS \| Reactome Pathway
R-HSA-168256	Immune System TAS \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins TAS \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling TAS \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
hsa04530	Tight junction

NCI Nature PID Pathways

Pathway ID	Pathway Name
syndecan_1_pathway	Syndecan-1-mediated signaling events
syndecan_2_pathway	Syndecan-2-mediated signaling events
syndecan_3_pathway	Syndecan-3-mediated signaling events