| Gene |
PPP1R12A
|
| Protein Name |
MYPT1_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit) |
| Protein Family |
N/A |
| NCBI Gene ID |
4659
|
| UniProt ID |
O14974
|
| Enzyme Class |
- |
| Molecular Weight |
115281 |
| Protein Length |
1030 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cytoplasm |
| Function (UniProt annotation) |
Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity. |
| Gene Ontology |
GO:0000278; GO:0000776; GO:0004857; GO:0005654; GO:0005737; GO:0005813; GO:0005829; GO:0005925; GO:0006470; GO:0007098; GO:0007165; GO:0015629; GO:0019208; GO:0019901; GO:0030018; GO:0030155; GO:0031672; GO:0035507; GO:0035508; GO:0035690; GO:0043086; GO:0043292; GO:0045944; GO:0046822; GO:0071889; GO:0072357 |
