| Gene |
SMAD7
|
| Protein Name |
SMAD7_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Mothers against decapentaplegic homolog 7 (MAD homolog 7) (Mothers against DPP homolog 7) (Mothers against decapentaplegic homolog 8) (MAD homolog 8) (Mothers against DPP homolog 8) (SMAD family member 7) (SMAD 7) (Smad7) (hSMAD7) |
| Protein Family |
Dwarfin/SMAD family |
| NCBI Gene ID |
4092
|
| UniProt ID |
O15105
|
| Enzyme Class |
- |
| Molecular Weight |
46426 |
| Protein Length |
426 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Nucleus |
| Function (UniProt annotation) |
Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. |
| Gene Ontology |
GO:0000122; GO:0000981; GO:0001650; GO:0001657; GO:0002725; GO:0005518; GO:0005634; GO:0005654; GO:0005667; GO:0005737; GO:0005813; GO:0005829; GO:0005886; GO:0007179; GO:0008013; GO:0010717; GO:0010719; GO:0010801; GO:0010944; GO:0016579; GO:0017015; GO:0022409; GO:0030336; GO:0030509; GO:0030512; GO:0030514; GO:0030617; GO:0031397; GO:0031398; GO:0031625; GO:0032436; GO:0032925; GO:0032991; GO:0033137; GO:0034333; GO:0034616; GO:0034629; GO:0034713; GO:0043433; GO:0044212; GO:0045944; GO:0046872; GO:0048185; GO:0048844; GO:0050821; GO:0051444; GO:0055010; GO:0055117; GO:0060373; GO:0060389; GO:0060394; GO:0060412; GO:0070411; GO:0071560; GO:1990830; GO:2000317; GO:2000320 |
