CaMKipedia | Result

Graphics credits: COMPARTMENTS | More Info

Sequence Viewer

Gene

Melk

Synonyms

Kiaa0175 Pk38

Protein Name

Maternal embryonic leucine zipper kinase

UniProt ID

Q61846

Ensembl Gene ID

10090.ENSMUSP00000043806

NCBI Gene ID

17279

Molecular Weight

72,729

Protein Length

643

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 4bfm)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

2.7.11.1; 2.7.10.2 (BRENDA)

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.; ATP + a protein = ADP + a phosphoprotein.

Localization

Cell membrane Peripheral membrane protein

Function

Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis.

Gene Ontology

GO:0004672; GO:0004674; GO:0004715; GO:0005509; GO:0005524; GO:0005634; GO:0005737; GO:0005886; GO:0005938; GO:0006468; GO:0006915; GO:0007049; GO:0008283; GO:0008289; GO:0008631; GO:0030097; GO:0035556; GO:0043065; GO:0046777; GO:0061351

Gene Ontology

Substrate	Organism	PSite	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
Strap (Q9Z1Z2)	Mus musculus	S188	NFNMSVSSMEYIPEG	-	0.2002	TP	certain	experimental	55 \| 23 \| 73 \| 20 \| 72 \| 9 \|	25485581	-	-
SMAD2 (Q15796)	Homo sapiens	S245	NQSMDTGSPAELSPT	0.477	0.7459	TP	certain	experimental	23 \| 72 \| 9 \|	20659902	-	-
SMAD3 (P84022)	Homo sapiens	S204	NHSMDAGSPNLSPNP	0.185	0.8125	TP	certain	experimental	23 \| 72 \| 9 \|	20659902	-	-
SMAD4 (Q13485)	Homo sapiens	S343	GETFKVPSSCPIVTV	0.675	0.2503	TP	certain	experimental	23 \| 72 \| 9 \|	20659902	-	-
MAP3K5 (Q99683)	Homo sapiens	T838	GINPCTETFTGTLQY	0.596	0.2399	TP	certain	experimental	72 \| 9 \| 55 \|	18948261	-	-
SMAD6 (O43541)	Homo sapiens	T176	EQELKTVTYSLLKRL	0.497	0.2541	TP	certain	experimental	72 \| 9 \|	20659902	-	-
SMAD7 (O15105)	Homo sapiens	T96	EADLKALTHSVLKKL	0.217	0.4685	TP	certain	experimental	23 \| 72 \| 9 \|	20659902	-	-
PDPK1 (O15530)	Homo sapiens	T354	WENLHQQTPPKLTAY	0.619	0.3392	TP	certain	experimental	72 \| 55 \| 9 \|	22544756	-	-

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system TAS \| Reactome Pathway
R-HSA-168256	Immune System TAS \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins TAS \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling TAS \| Reactome Pathway

No KEGG pathways found

No NCI Nature pathways found