| Gene |
ARPC5
|
| Protein Name |
ARPC5_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Actin-related protein 2/3 complex subunit 5 (Arp2/3 complex 16 kDa subunit) (p16-ARC) |
| Protein Family |
ARPC5 family |
| NCBI Gene ID |
10092
|
| UniProt ID |
O15511
|
| Enzyme Class |
- |
| Molecular Weight |
16320 |
| Protein Length |
151 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cytoplasm, cytoskeleton |
| Function (UniProt annotation) |
Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). |
| Gene Ontology |
GO:0005200; GO:0005576; GO:0005634; GO:0005737; GO:0005768; GO:0005829; GO:0005885; GO:0005925; GO:0014909; GO:0015629; GO:0016477; GO:0021769; GO:0030011; GO:0030027; GO:0030036; GO:0030426; GO:0034314; GO:0034774; GO:0035861; GO:0038096; GO:0043312; GO:0048013; GO:0051015; GO:0051639; GO:0061024; GO:0061842; GO:0070062; GO:0097581; GO:1904813 |
