CaMKinet | Result

Sequence Viewer

Parameter	Value
Gene	Mdm4
Protein Name	MDM4_MOUSE
Organism	Mus musculus (Mouse)
Alternative name(s)	Protein Mdm4 (Double minute 4 protein) (Mdm2-like p53-binding protein) (Protein Mdmx) (p53-binding protein Mdm4)
Protein Family	MDM2/MDM4 family
NCBI Gene ID	17248
UniProt ID	O35618
Enzyme Class	-
Molecular Weight	54963
Protein Length	489
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	Nucleus.
Function (UniProt annotation)	Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions. The short isoform is a more potent inhibitor of TP53 activity than the long isoform.
Gene Ontology	GO:0000122; GO:0002027; GO:0003170; GO:0003181; GO:0003203; GO:0003281; GO:0003283; GO:0005634; GO:0008283; GO:0008284; GO:0019899; GO:0030330; GO:0042177; GO:0043066; GO:0045023; GO:0046872; GO:0065003; GO:0071157

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
CHEK1 (O14757)	Homo sapiens	S367	PDCRRTISAPVVRPK	N/A	0.3948	-	-	-	-	-	-	In vivo

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

No KEGG pathways found

No NCI Nature pathways found