| Gene |
SIAH2
|
| Protein Name |
SIAH2_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
E3 ubiquitin-protein ligase SIAH2 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase SIAH2) (Seven in absentia homolog 2) (Siah-2) (hSiah2) |
| Protein Family |
SINA (Seven in absentia) family |
| NCBI Gene ID |
6478
|
| UniProt ID |
O43255
|
| Enzyme Class |
2.3.2.27 |
| Molecular Weight |
34615 |
| Protein Length |
324 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. |
| Localization |
Cytoplasm |
| Function (UniProt annotation) |
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (GPS2, POU2AF1, PML, NCOR1), a cell surface receptor (DCC), an antiapoptotic protein (BAG1), and a protein involved in synaptic vesicle function in neurons (SYP). Mediates ubiquitination and proteasomal degradation of DYRK2 in response to hypoxia. It is thereby involved in apoptosis, tumor suppression, cell cycle, transcription and signaling processes. Has some overlapping function with SIAH1. Triggers the ubiquitin-mediated degradation of TRAF2, whereas SIAH1 does not. Promotes monoubiquitination of SNCA. |
| Gene Ontology |
GO:0000209; GO:0003714; GO:0004842; GO:0005654; GO:0005737; GO:0005769; GO:0005829; GO:0006511; GO:0006915; GO:0007049; GO:0007264; GO:0007275; GO:0008270; GO:0016579; GO:0031396; GO:0031624; GO:0043005; GO:0043025; GO:0043066; GO:0043154; GO:0043161; GO:0043231; GO:0044257; GO:0044267; GO:0061630; GO:0090090; GO:1902842; GO:2001237 |
