| Gene |
SMAD6
|
| Protein Name |
SMAD6_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Mothers against decapentaplegic homolog 6 (MAD homolog 6) (Mothers against DPP homolog 6) (SMAD family member 6) (SMAD 6) (Smad6) (hSMAD6) |
| Protein Family |
Dwarfin/SMAD family |
| NCBI Gene ID |
4091
|
| UniProt ID |
O43541
|
| Enzyme Class |
- |
| Molecular Weight |
53497 |
| Protein Length |
496 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Nucleus |
| Function (UniProt annotation) |
Acts as a mediator of TGF-beta and BMP antiflammatory activity. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes. May block the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding. Binds to regulatory elements in target promoter regions. |
| Gene Ontology |
GO:0000978; GO:0000981; GO:0001657; GO:0003148; GO:0003180; GO:0003183; GO:0003184; GO:0003281; GO:0003682; GO:0005634; GO:0005667; GO:0005737; GO:0005794; GO:0005829; GO:0006955; GO:0007179; GO:0007352; GO:0008285; GO:0010991; GO:0016604; GO:0030279; GO:0030509; GO:0030512; GO:0030514; GO:0030617; GO:0031589; GO:0031625; GO:0032991; GO:0034616; GO:0034713; GO:0035904; GO:0042802; GO:0043066; GO:0043627; GO:0044212; GO:0045444; GO:0045668; GO:0046872; GO:0060394; GO:0060976; GO:0070410; GO:0070411; GO:0070412; GO:0070698; GO:1902895 |
