CaMKinet | Result

Sequence Viewer

Parameter	Value
Gene	PLRG1
Protein Name	PLRG1_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Pleiotropic regulator 1
Protein Family	WD repeat PRL1/PRL2 family
NCBI Gene ID	5356
UniProt ID	O43660
Enzyme Class	-
Molecular Weight	57194
Protein Length	514
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	Nucleus
Function (UniProt annotation)	Involved in pre-mRNA splicing as component of the spliceosome (PubMed:28502770, PubMed:28076346). Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing (PubMed:11101529, PubMed:11544257).
Gene Ontology	GO:0000398; GO:0000974; GO:0001650; GO:0005634; GO:0005654; GO:0016607; GO:0031965; GO:0034504; GO:0071007; GO:0071013; GO:0080008; GO:1900087

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
CHEK1 (O14757)	Homo sapiens	S119	TKIQRMPSESAAQSL	0.992	0.6375	-	-	-	-	-	-	in-vitro

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

No KEGG pathways found

No NCI Nature pathways found