| Gene |
Dapk3
|
| Protein Name |
DAPK3_MOUSE |
| Organism |
Mus musculus (Mouse) |
| Alternative name(s) |
Death-associated protein kinase 3 (DAP kinase 3) (EC 2.7.11.1) (DAP-like kinase) (Dlk) (MYPT1 kinase) (ZIP-kinase) |
| Protein Family |
Protein kinase superfamily |
| NCBI Gene ID |
13144
|
| UniProt ID |
O54784
|
| Enzyme Class |
2.7.11.1 |
| Molecular Weight |
51422 |
| Protein Length |
448 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
ATP + a protein = ADP + a phosphoprotein. |
| Localization |
Nucleus |
| Function (UniProt annotation) |
Serine/threonine kinase which is involved in the regulation of apoptosis, autophagy, transcription, translation and actin cytoskeleton reorganization. Regulates both type I (caspase-dependent) apoptotic and type II (caspase-independent) autophagic cell deaths signal, depending on the cellular setting. Involved in formation of promyelocytic leukemia protein nuclear body (PML-NB). Involved in apoptosis involving PAWR which mediates cytoplasmic relocation; in vitro phosphorylates PAWR (By similarity). Phosphorylates MYL12B in non-muscle cells leading to reorganization of actin cytoskeleton such as in regulation of cell polarity and cell migration. Positively regulates canonical Wnt/beta-catenin signaling through interaction with NLK and TCF7L2; disrupts the NLK-TCF7L2 complex thereby influencing the phosphorylation of TCF7L2 by NLK. Phosphorylates STAT3 and enhances its transcriptional activity. Enhances transcription from AR-responsive promoters in a hormone- and kinase-dependent manner. Phosphorylates histone H3 on 'Thr-11' at centromeres during mitosis (By similarity). Phosphorylates RPL13A on 'Ser-77' upon interferon-gamma activation which is causing RPL13A release from the ribosome, RPL13A association with the GAIT complex and its subsequent involvement in transcript-selective translation inhibition. |
| Gene Ontology |
GO:0000775; GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0005815; GO:0005884; GO:0006325; GO:0006468; GO:0006915; GO:0007346; GO:0008022; GO:0008360; GO:0016301; GO:0016605; GO:0017048; GO:0017148; GO:0030182; GO:0030335; GO:0035556; GO:0042802; GO:0042803; GO:0043065; GO:0043519; GO:0043522; GO:0045121; GO:0046777; GO:0051893; GO:0071346; GO:0090263; GO:0097190; GO:2000249; GO:2001241 |
