| Gene |
Arhgef7
|
| Protein Name |
ARHG7_RAT |
| Organism |
Rattus norvegicus (Rat) |
| Alternative name(s) |
Rho guanine nucleotide exchange factor 7 (Beta-Pix) (PAK-interacting exchange factor beta) |
| Protein Family |
N/A |
| NCBI Gene ID |
114559
|
| UniProt ID |
O55043
|
| Enzyme Class |
- |
| Molecular Weight |
73140 |
| Protein Length |
646 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cell junction, focal adhesion Note=Detected at cell adhesions. A small proportion is detected at focal adhesions. |
| Function (UniProt annotation) |
Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions. May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons (By similarity). |
| Gene Ontology |
GO:0001726; GO:0005085; GO:0005089; GO:0005737; GO:0005925; GO:0005938; GO:0007264; GO:0019901; GO:0030027; GO:0030032; GO:0030426; GO:0032991; GO:0035023; GO:0043065; GO:0043615; GO:0098974; GO:0098982; GO:0099140 |
