CaMKinet | Result

Sequence Viewer

Parameter	Value
Gene	TBC1D4
Protein Name	TBCD4_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160)
Protein Family	N/A
NCBI Gene ID	9882
UniProt ID	O60343
Enzyme Class	-
Molecular Weight	146563
Protein Length	1298
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	Cytoplasm Note=Isoform 2 shows a cytoplasmic perinuclear localization in a myoblastic cell line in resting and insulin-stimulated cells.
Function (UniProt annotation)	May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake.
Gene Ontology	GO:0005096; GO:0005829; GO:0006886; GO:0016192; GO:0017137; GO:0031339; GO:0031982; GO:0032869; GO:0090630

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
CHEK1 (O14757)	Homo sapiens	S588	RMRGRLGSVDSFERS	0.583	0.6427	-	-	-	-	-	-	in-vitro
CHEK1 (O14757)	Homo sapiens	S485	LVIQRHLSSLTDNEQ	0.54	0.3286	-	-	-	-	-	-	in-vitro

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

No KEGG pathways found

No NCI Nature pathways found