CaMKinet | Result

Sequence Viewer

Parameter	Value
Gene	TLR5
Protein Name	TLR5_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Toll-like receptor 5 (Toll/interleukin-1 receptor-like protein 3)
Protein Family	Toll-like receptor family
NCBI Gene ID	7100
UniProt ID	O60602
Enzyme Class	-
Molecular Weight	97834
Protein Length	858
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	Membrane
Function (UniProt annotation)	Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
Gene Ontology	GO:0002755; GO:0004888; GO:0005149; GO:0005886; GO:0006954; GO:0016021; GO:0032757; GO:0034123; GO:0034146; GO:0042742; GO:0045087; GO:0050707; GO:0071260

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
PRKD1 (Q15139)	Homo sapiens	S805	YQLMKHQSIRGFVQK	0.044	0.1048	-	-	-	-	-	-	In vitro and in vivo

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
hsa04620	Toll-like receptor signaling pathway
hsa05130	Pathogenic Escherichia coli infection

No NCI Nature pathways found