| Gene |
REV3L
|
| Protein Name |
REV3L_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
DNA polymerase zeta catalytic subunit (EC 2.7.7.7) (Protein reversionless 3-like) (REV3-like) (hREV3) |
| Protein Family |
DNA polymerase type-B family |
| NCBI Gene ID |
5980
|
| UniProt ID |
O60673
|
| Enzyme Class |
2.7.7.7 |
| Molecular Weight |
352776 |
| Protein Length |
3130 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). |
| Localization |
Nucleus |
| Function (UniProt annotation) |
Catalytic subunit of the DNA polymerase zeta complex, an error-prone polymerase specialized in translesion DNA synthesis (TLS). Lacks an intrinsic 3'-5' exonuclease activity and thus has no proofreading function. |
| Gene Ontology |
GO:0000166; GO:0003677; GO:0003887; GO:0005654; GO:0005730; GO:0006261; GO:0016035; GO:0042276; GO:0046872; GO:0051539; GO:0090305 |
