Graphics credits: COMPARTMENTS | More Info
| Parameter | Value |
|---|---|
| Gene | PFKFB2 |
| Protein Name | F262_HUMAN |
| Organism | Homo sapiens (Human) |
| Alternative name(s) | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (6PF-2-K/Fru-2,6-P2ase 2) (PFK/FBPase 2) (6PF-2-K/Fru-2,6-P2ase heart-type isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)] |
| Protein Family | Phosphoglycerate mutase family |
| NCBI Gene ID | 5208 |
| UniProt ID | O60825 |
| Enzyme Class | 2.7.1.105; 3.1.3.46 |
| Molecular Weight | 58477 |
| Protein Length | 505 |
| Protein Domain | InterPro | Pfam |
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase | SwissModel |
| Gene Expression | Gene Expression Atlas |
| Function and Disease | OMIM |
| Protein-protein Interaction Database | STRING | IntAct | MINT |
| Kinase Database | Phospho.ELM | PhosphoSite | NetworKIN |
| Catalytic Activity (UniProt annotation) | Beta-D-fructose 2 |
| Localization | N/A |
| Function (UniProt annotation) | Synthesis and degradation of fructose 2,6-bisphosphate. |
| Gene Ontology | GO:0003873; GO:0004331; GO:0005524; GO:0005634; GO:0005654; GO:0005829; GO:0006000; GO:0006003; GO:0006007; GO:0006089; GO:0006096; GO:0009749; GO:0019901; GO:0032024; GO:0033133; GO:0045821 |
| Gene Name | Organism | P-Site | Sequence(+/-7) | Conservation | Disorder | Curator Assessment | Reliability | Evidence Class | Evidence Logic | PubMed | Phospho-ELM | PhosphoSite-Plus |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Prkaa1 (P54645) | Rattus norvegicus | S466 | PVRMRRNSFTPLSSS | 0.089 | 0.5901 | TP | certain | experimental | 214 | 133 | 8 | 73 | 55 | | 11069105 | - |
|
| PRKAA1 (Q13131) | Homo sapiens | S466 | PVRMRRNSFTPLSSS | 0.089 | 0.5901 | - | - | - | - | - | - |
|
| PRKAA2 (P54646) | Homo sapiens | S466 | PVRMRRNSFTPLSSS | 0.089 | 0.5901 | - | - | - | - | - | - |
|
Reactome Pathways
KEGG Pathways
| Pathway ID | Pathway Name |
|---|---|
| hsa00051 | Fructose and mannose metabolism |
No NCI Nature pathways found