| Gene |
PHF2
|
| Protein Name |
PHF2_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Lysine-specific demethylase PHF2 (EC 1.14.11.-) (GRC5) (PHD finger protein 2) |
| Protein Family |
JHDM1 histone demethylase family |
| NCBI Gene ID |
5253
|
| UniProt ID |
O75151
|
| Enzyme Class |
1.14.11.- |
| Molecular Weight |
120775 |
| Protein Length |
1096 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Nucleus, nucleolus |
| Function (UniProt annotation) |
Lysine demethylase that demethylates both histones and non-histone proteins. Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B. Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA. |
| Gene Ontology |
GO:0000776; GO:0000777; GO:0001889; GO:0005506; GO:0005634; GO:0005654; GO:0005730; GO:0006482; GO:0008270; GO:0032452; GO:0032454; GO:0035064; GO:0051213; GO:0061188 |
