CaMKinet | Result

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Sequence Viewer

Parameter	Value
Gene	ULK1
Protein Name	ULK1_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Autophagy-related protein 1 homolog) (ATG1) (hATG1) (Unc-51-like kinase 1)
Protein Family	Protein kinase superfamily
NCBI Gene ID	8408
UniProt ID	O75385
Enzyme Class	2.7.11.1
Molecular Weight	112631
Protein Length	1050
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	ATP + a protein = ADP + a phosphoprotein.
Localization	Cytoplasm, cytosol
Function (UniProt annotation)	Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation. May also phosphorylate SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165).
Gene Ontology	GO:0000045; GO:0000407; GO:0004674; GO:0005524; GO:0005737; GO:0005741; GO:0005776; GO:0005789; GO:0005829; GO:0006468; GO:0006914; GO:0007165; GO:0008104; GO:0010506; GO:0016020; GO:0016236; GO:0016241; GO:0016301; GO:0017137; GO:0018105; GO:0018107; GO:0030424; GO:0031102; GO:0031175; GO:0031333; GO:0031669; GO:0034045; GO:0042594; GO:0042802; GO:0044877; GO:0046777; GO:0048675; GO:0051020; GO:0055037; GO:0075044; GO:0097629; GO:0097632; GO:0097635; GO:1990316; GO:2000786

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
PRKAA1 (Q13131)	Homo sapiens	S637	FDFPKTPSSQNLLAL	0.789	N/A	-	-	experimental	72 \| 214 \|	21205641	-	In vivo
PRKAA1 (Q13131)	Homo sapiens	S638	FDFPKTPSSQNLLAL	0.789	0.494	-	-	-	-	-	-	In vivo
PRKAA2 (P54646)	Homo sapiens	S317	SHLASPPSLGEMQQL	0.841	0.805	-	-	-	-	-	-	-
PRKAA2 (P54646)	Homo sapiens	S556	GLGCRLHSAPNLSDL	0.945	0.5758	-	-	-	-	-	-	-
PRKAA2 (P54646)	Homo sapiens	S638	FDFPKTPSSQNLLAL	0.789	0.494	-	-	-	-	-	-	-
PRKAA1 (Q13131)	Homo sapiens	S317	SHLASPPSLGEMQQL	0.841	0.805	-	-	-	-	-	-	-
PRKAA1 (Q13131)	Homo sapiens	S467	SAIRRSGSTSPLGFA	0.864	0.7843	-	-	-	-	-	-	-
PRKAA1 (Q13131)	Homo sapiens	S556	GLGCRLHSAPNLSDL	0.945	0.5758	-	-	-	-	-	-	-

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
hsa04140	Regulation of autophagy
hsa04150	mTOR signaling pathway

No NCI Nature pathways found