| Gene |
E2F6
|
| Protein Name |
E2F6_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Transcription factor E2F6 (E2F-6) |
| Protein Family |
E2F/DP family |
| NCBI Gene ID |
1876
|
| UniProt ID |
O75461
|
| Enzyme Class |
- |
| Molecular Weight |
31844 |
| Protein Length |
281 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Nucleus. |
| Function (UniProt annotation) |
Inhibitor of E2F-dependent transcription. Binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. Has a preference for the 5'-TTTCCCGC-3' E2F recognition site. E2F6 lacks the transcriptional activation and pocket protein binding domains. Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression. May silence expression via the recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity. Overexpression delays the exit of cells from the S-phase. |
| Gene Ontology |
GO:0000083; GO:0000122; GO:0000981; GO:0001077; GO:0001078; GO:0003677; GO:0003714; GO:0005634; GO:0005654; GO:0008134; GO:0043565; GO:0045944; GO:0046983; GO:0051726; GO:0070317; GO:0071339; GO:0090575 |
