CaMKinet | Result

Sequence Viewer

Parameter	Value
Gene	PLEKHG5
Protein Name	PKHG5_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Pleckstrin homology domain-containing family G member 5 (PH domain-containing family G member 5) (Guanine nucleotide exchange factor 720) (GEF720)
Protein Family	N/A
NCBI Gene ID	57449
UniProt ID	O94827
Enzyme Class	-
Molecular Weight	117451
Protein Length	1062
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	Cytoplasm
Function (UniProt annotation)	Guanine nucleotide exchange factor that activates RHOA and maybe the NF-kappa-B signaling pathway. Involved in the control of neuronal cell differentiation. Plays a role in angiogenesis through regulation of endothelial cells chemotaxis.
Gene Ontology	GO:0005085; GO:0005089; GO:0005737; GO:0005829; GO:0005886; GO:0005911; GO:0007186; GO:0030027; GO:0030139; GO:0035023; GO:0035767; GO:0043065; GO:0043123; GO:0048471; GO:0051056; GO:0098793; GO:0099575

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
PRKD1 (Q15139)	Homo sapiens	S92	PRTSPAVDLEEEEEE	N/A	N/A	-	-	-	-	-	-	-

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

No KEGG pathways found

No NCI Nature pathways found