| Gene |
LATS1
|
| Protein Name |
LATS1_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts) |
| Protein Family |
Protein kinase superfamily |
| NCBI Gene ID |
9113
|
| UniProt ID |
O95835
|
| Enzyme Class |
2.7.11.1 |
| Molecular Weight |
126870 |
| Protein Length |
1130 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
ATP + a protein = ADP + a phosphoprotein. |
| Localization |
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Localizes to the centrosomes throughout interphase but migrates to the mitotic apparatus, including spindle pole bodies, mitotic spindle, and midbody, during mitosis. |
| Function (UniProt annotation) |
Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDK1 kinase activity. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. May also play a role in endocrine function. Plays a role in mammary gland epithelial cells differentiation, both through the Hippo signaling pathway and the intracellular estrogen receptor signaling pathway by promoting the degradation of ESR1 (PubMed:28068668). |
| Gene Ontology |
GO:0000082; GO:0000086; GO:0000287; GO:0000819; GO:0000922; GO:0001827; GO:0001828; GO:0004674; GO:0005524; GO:0005815; GO:0005829; GO:0006468; GO:0009755; GO:0018105; GO:0019901; GO:0030216; GO:0030331; GO:0030833; GO:0033138; GO:0033146; GO:0034613; GO:0035329; GO:0035556; GO:0043065; GO:0043254; GO:0045736; GO:0046620; GO:0051220; GO:0051301; GO:0060644; GO:0090090; GO:2000058 |
