CaMKipedia | Result

Graphics credits: COMPARTMENTS | More Info

Sequence Viewer

Gene

NUAK1

Synonyms

ARK5 KIAA0537 OMPHK1

Protein Name

NUAK family SNF1-like kinase 1

UniProt ID

O60285

Ensembl Gene ID

9606.ENSP00000261402

NCBI Gene ID

9891

Molecular Weight

74,305

Protein Length

661

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : N/A)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

2.7.11.1 (BRENDA)

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

ATP + a protein = ADP + a phosphoprotein.

Localization

Nucleus Cytoplasm

Function

Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1. May be involved in DNA damage response: phosphorylates p53/TP53 at 'Ser-15' and 'Ser-392' and is recruited to the CDKN1A/WAF1 promoter to participate to transcription activation by p53/TP53. May also act as a tumor malignancy-associated factor by promoting tumor invasion and metastasis under regulation and phosphorylation by AKT1. Suppresses Fas-induced apoptosis by mediating phosphorylation of CASP6, thereby suppressing the activation of the caspase and the subsequent cleavage of CFLAR. Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with STK11, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair (PubMed:25329316).

Gene Ontology

GO:0001650; GO:0002039; GO:0004674; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0006468; GO:0006974; GO:0007155; GO:0015630; GO:0030155; GO:0035507; GO:0035556; GO:0042127; GO:0046872; GO:1901796; GO:2000772

Gene Ontology

Substrate	Organism	PSite	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
LATS1 * (O95835)	Homo sapiens	S464	NIPVRSNSFNNPLGN	0.913	0.7209	TP	certain	experimental	23 \| 9 \| 55 \|	19927127	-	-
PPP1R12A (O14974)	Homo sapiens	S445	LGLRKTGSYGALAEI	0.674	0.5017	TP	certain	experimental	135 \| 30 \| 9 \|	20354225	-	-
PPP1R12A (O14974)	Homo sapiens	S472	AGVTRSASSPRLSSS	0.669	0.7369	TP	certain	experimental	135 \| 30 \| 9 \|	20354225	-	-
PPP1R12A (O14974)	Homo sapiens	S910	SLLGRSGSYSYLEER	0.14	0.5055	TP	likely	experimental	135 \| 30 \| 9 \|	20354225	-	-
CASP6 (P55212)	Homo sapiens	S257	TLVNRKVSQRRVDFC	0.72	0.1791	TP	certain	experimental	72 \| 30 \| 8 \|	22483120	-	-
TP53 * (P04637)	Homo sapiens	S15	PSVEPPLSQETFSDL	0.83	0.7163	TP	certain	experimental	23 \| 72 \| 55 \| 73 \| 9 \|	21317932	-	-
TP53 * (P04637)	Homo sapiens	S392	FKTEGPDSD______	0.808	0.7755	TP	certain	experimental	23 \| 72 \| 55 \| 73 \| 9 \|	21317932	-	-
MAPT (P10636-8)	Homo sapiens	S356	RVQSKIGSLDNITHV	-	-	-	-	-	-	-	-	in-vitro and in-vivo
MAPT (P10636-8)	Homo sapiens	S262	NVKSKIGSTENLKHQ	-	-	-	-	-	-	-	-	in-vitro and in-vivo
CDKN1A (P38936)	Homo sapiens	S146	GRKRRQTSMTDFYHS	0.575	0.725	-	-	-	-	-	-	-

Kinase

Substrate

Interactor

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system TAS \| Reactome Pathway
R-HSA-168256	Immune System TAS \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins TAS \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling TAS \| Reactome Pathway

No KEGG pathways found

No NCI Nature pathways found