| Gene |
SNAI1
|
| Protein Name |
SNAI1_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Zinc finger protein SNAI1 (Protein snail homolog 1) (Protein sna) |
| Protein Family |
Snail C2H2-type zinc-finger protein family |
| NCBI Gene ID |
6615
|
| UniProt ID |
O95863
|
| Enzyme Class |
- |
| Molecular Weight |
29083 |
| Protein Length |
264 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Nucleus Cytoplasm. Note=Once phosphorylated (probably on Ser-107, Ser-111, Ser-115 and Ser-119) it is exported from the nucleus to the cytoplasm where subsequent phosphorylation of the destruction motif and ubiquitination involving BTRC occurs. |
| Function (UniProt annotation) |
Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. During EMT, involved with LOXL2 in negatively regulating pericentromeric heterochromatin transcription (By similarity). SNAI1 recruits LOXL2 to pericentromeric regions to oxidize histone H3 and repress transcription which leads to release of heterochromatin component CBX5/HP1A, enabling chromatin reorganization and acquisition of mesenchymal traits (By similarity). Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself. |
| Gene Ontology |
GO:0000122; GO:0000977; GO:0000981; GO:0001078; GO:0001227; GO:0001649; GO:0001707; GO:0001837; GO:0003180; GO:0003198; GO:0005634; GO:0005654; GO:0005721; GO:0005737; GO:0005829; GO:0010718; GO:0010957; GO:0016477; GO:0019900; GO:0030335; GO:0031069; GO:0043518; GO:0045893; GO:0046872; GO:0060021; GO:0060536; GO:0060707; GO:0060806; GO:0060972; GO:0061314; GO:0070828; GO:0070888; GO:1902230; GO:2000810 |
