| Gene |
MBP
|
| Protein Name |
MBP_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Myelin basic protein (MBP) (Myelin A1 protein) (Myelin membrane encephalitogenic protein) |
| Protein Family |
Myelin basic protein family |
| NCBI Gene ID |
4155
|
| UniProt ID |
P02686
|
| Enzyme Class |
- |
| Molecular Weight |
33117 |
| Protein Length |
304 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Myelin membrane; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic side of myelin.; Isoform 3: Nucleus Note=Targeted to nucleus in oligodendrocytes. |
| Function (UniProt annotation) |
The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation. |
| Gene Ontology |
GO:0000165; GO:0002020; GO:0005516; GO:0005622; GO:0005634; GO:0005886; GO:0006955; GO:0007268; GO:0007417; GO:0007605; GO:0008366; GO:0009636; GO:0009986; GO:0019911; GO:0021762; GO:0032991; GO:0033269; GO:0034115; GO:0035633; GO:0042552; GO:0043025; GO:0043209; GO:0043218; GO:0061024; GO:0071944; GO:1904209; GO:1904685; GO:2000778 |
