| Gene |
CACNA1S
|
| Protein Name |
CAC1S_RABIT |
| Organism |
Oryctolagus cuniculus (Rabbit) |
| Alternative name(s) |
Voltage-dependent L-type calcium channel subunit alpha-1S (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle) (Dihydropyridine receptor alpha-1S subunit) (DHPR) (Voltage-gated calcium channel subunit alpha Cav1.1) |
| Protein Family |
Calcium channel alpha-1 subunit (TC 1.A.1.11) family |
| NCBI Gene ID |
100009585
|
| UniProt ID |
P07293
|
| Enzyme Class |
- |
| Molecular Weight |
212029 |
| Protein Length |
1873 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cell membrane, sarcolemma |
| Function (UniProt annotation) |
Pore-forming, alpha-1S subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle (PubMed:9465115, PubMed:15201141, PubMed:25548159, PubMed:27621462, PubMed:29078335, PubMed:29467163). Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle via their interaction with RYR1, which triggers Ca(2+) release from the sarcplasmic reticulum and ultimately results in muscle contraction (PubMed:9465115 PubMed:15201141, PubMed:27621462). Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. |
| Gene Ontology |
GO:0005245; GO:0005516; GO:0005887; GO:0030315; GO:0044325; GO:0046872; GO:0060314; GO:0070588; GO:0071313; GO:1990454 |
