CaMKinet | Result

Sequence Viewer

Parameter	Value
Gene	Gja1
Protein Name	CXA1_RAT
Organism	Rattus norvegicus (Rat)
Alternative name(s)	Gap junction alpha-1 protein (Connexin-43) (Cx43) (Gap junction 43 kDa heart protein)
Protein Family	Connexin family
NCBI Gene ID	24392
UniProt ID	P08050
Enzyme Class	-
Molecular Weight	43031
Protein Length	382
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	Cell membrane
Function (UniProt annotation)	Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract (By similarity). May play a role in cell growth inhibition through the regulation of NOV expression and localization (PubMed:15181016). Plays an essential role in gap junction communication in the ventricles (By similarity).
Gene Ontology	GO:0000139; GO:0001649; GO:0001701; GO:0001764; GO:0001937; GO:0001947; GO:0002070; GO:0002088; GO:0002544; GO:0002931; GO:0003104; GO:0003158; GO:0003294; GO:0005102; GO:0005243; GO:0005737; GO:0005741; GO:0005764; GO:0005768; GO:0005769; GO:0005770; GO:0005771; GO:0005789; GO:0005794; GO:0005829; GO:0005882; GO:0005886; GO:0005887; GO:0005916; GO:0005921; GO:0005922; GO:0006915; GO:0007154; GO:0007204; GO:0007267; GO:0007507; GO:0007512; GO:0008285; GO:0009268; GO:0009749; GO:0010232; GO:0010628; GO:0010629; GO:0010643; GO:0010644; GO:0010652; GO:0015867; GO:0016020; GO:0016264; GO:0016324; GO:0016328; GO:0017124; GO:0019904; GO:0022898; GO:0030165; GO:0030308; GO:0030500; GO:0030660; GO:0032024; GO:0032355; GO:0032496; GO:0032526; GO:0032991; GO:0034405; GO:0042733; GO:0043292; GO:0043403; GO:0043434; GO:0045121; GO:0045669; GO:0045732; GO:0045844; GO:0045907; GO:0046697; GO:0046850; GO:0048487; GO:0048514; GO:0048812; GO:0051259; GO:0051924; GO:0055085; GO:0060044; GO:0060156; GO:0060307; GO:0060371; GO:0060373; GO:0061045; GO:0061337; GO:0071253; GO:0071260; GO:0071374; GO:0071467; GO:0097110; GO:0097718; GO:0097755; GO:0120162; GO:1905867; GO:1990782; GO:2000279; GO:2000810; GO:2000987

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
CAMK2A (Q9UQM7)	Homo sapiens	S244	KDRVKGRSDPYHATT	N/A	0.4725	-	-	-	-	-	-	In vitro
CAMK2A (Q9UQM7)	Homo sapiens	S330	AGSTISNSHAQPFDF	N/A	0.725	-	-	-	-	-	-	In vitro
CAMK2A (Q9UQM7)	Homo sapiens	S364	AIVDQRPSSRASSRA	N/A	0.805	-	-	-	-	-	-	In vitro
CAMK2A (Q9UQM7)	Homo sapiens	S365	IVDQRPSSRASSRAS	N/A	0.8198	-	-	-	-	-	-	In vitro
CAMK2A (Q9UQM7)	Homo sapiens	S369	RPSSRASSRASSRPR	N/A	0.9396	-	-	-	-	-	-	In vitro
CAMK2A (Q9UQM7)	Homo sapiens	S372	SRASSRASSRPRPDD	N/A	0.8828	-	-	-	-	-	-	In vitro
CAMK2A (Q9UQM7)	Homo sapiens	S373	RASSRASSRPRPDDL	N/A	0.8765	-	-	-	-	-	-	In vitro
CAMK2A (Q9UQM7)	Homo sapiens	S255	HATTGPLSPSKDCGS	N/A	0.4369	-	-	-	-	-	-	In vitro
CAMK2A (Q9UQM7)	Homo sapiens	S257	TTGPLSPSKDCGSPK	N/A	0.2884	-	-	-	-	-	-	In vitro
CAMK2A (Q9UQM7)	Homo sapiens	S296	VTGDRNNSSCRNYNK	N/A	0.4582	-	-	-	-	-	-	In vitro
CAMK2A (Q9UQM7)	Homo sapiens	S297	TGDRNNSSCRNYNKQ	N/A	0.5665	-	-	-	-	-	-	In vitro
CAMK2A (Q9UQM7)	Homo sapiens	S306	RNYNKQASEQNWANY	N/A	0.4507	-	-	-	-	-	-	In vitro
CAMK2A (Q9UQM7)	Homo sapiens	S314	EQNWANYSAEQNRMG	N/A	0.6576	-	-	-	-	-	-	In vitro
CAMK2A (Q9UQM7)	Homo sapiens	S325	NRMGQAGSTISNSHA	N/A	0.7547	-	-	-	-	-	-	In vitro
CAMK2A (Q9UQM7)	Homo sapiens	S328	GQAGSTISNSHAQPF	N/A	0.708	-	-	-	-	-	-	In vitro

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
rno04540	Gap junction
rno05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)

No NCI Nature pathways found