| Gene |
GLI1
|
| Protein Name |
GLI1_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Zinc finger protein GLI1 (Glioma-associated oncogene) (Oncogene GLI) |
| Protein Family |
GLI C2H2-type zinc-finger protein family |
| NCBI Gene ID |
2735
|
| UniProt ID |
P08151
|
| Enzyme Class |
- |
| Molecular Weight |
117904 |
| Protein Length |
1106 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cytoplasm |
| Function (UniProt annotation) |
Acts as a transcriptional activator (PubMed:19706761, PubMed:10806483, PubMed:19878745, PubMed:24311597, PubMed:24217340). Binds to the DNA consensus sequence 5'-GACCACCCA-3' (PubMed:2105456, PubMed:8378770, PubMed:24217340). May regulate the transcription of specific genes during normal development (PubMed:19706761). May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling (PubMed:19706761). Plays a role in cell proliferation and differentiation via its role in SHH signaling (Probable). |
| Gene Ontology |
GO:0000977; GO:0000978; GO:0000981; GO:0001649; GO:0003677; GO:0003682; GO:0003705; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0005930; GO:0007224; GO:0007283; GO:0007418; GO:0008017; GO:0008284; GO:0008589; GO:0009611; GO:0009913; GO:0009953; GO:0009954; GO:0021696; GO:0021938; GO:0021983; GO:0030324; GO:0030335; GO:0030850; GO:0043565; GO:0044212; GO:0045667; GO:0045740; GO:0045880; GO:0045893; GO:0045944; GO:0046872; GO:0048546; GO:0060032; GO:0060045; GO:0060070; GO:0090090; GO:0097421; GO:0097542; GO:0097546; GO:1902808; GO:2000345 |
