CaMKinet | Result

Sequence Viewer

Parameter	Value
Gene	CHRM2
Protein Name	ACM2_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Muscarinic acetylcholine receptor M2
Protein Family	G-protein coupled receptor 1 family
NCBI Gene ID	1129
UniProt ID	P08172
Enzyme Class	-
Molecular Weight	51715
Protein Length	466
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	Cell membrane
Function (UniProt annotation)	The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol.
Gene Ontology	GO:0004930; GO:0004993; GO:0005886; GO:0005887; GO:0006940; GO:0007186; GO:0007187; GO:0007188; GO:0007197; GO:0007207; GO:0007213; GO:0007268; GO:0007399; GO:0008016; GO:0008144; GO:0009615; GO:0016021; GO:0016907; GO:0030054; GO:0030425; GO:0030594; GO:0030665; GO:0032279; GO:0032280; GO:0043025; GO:0043679; GO:0061024; GO:0098978; GO:0098981; GO:0099055; GO:0099056; GO:1990763; GO:2000300

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
MKNK2 (Q9HBH9)	Homo sapiens	S286	EKESSNDSTSVSAVA	0.892	0.805	-	-	-	-	-	-	-
MKNK2 (Q9HBH9)	Homo sapiens	S288	ESSNDSTSVSAVASN	0.99	0.8125	-	-	-	-	-	-	-
MKNK2 (Q9HBH9)	Homo sapiens	S283	QGEEKESSNDSTSVS	0.516	0.6576	-	-	-	-	-	-	-
MKNK2 (Q9HBH9)	Homo sapiens	S234	NQDPVSPSLVQGRIV	0.936	0.5254	-	-	-	-	-	-	-
MKNK2 (Q9HBH9)	Homo sapiens	S290	SNDSTSVSAVASNMR	0.99	0.805	-	-	-	-	-	-	-
MKNK2 (Q9HBH9)	Homo sapiens	S232	VANQDPVSPSLVQGR	0.709	0.4979	-	-	-	-	-	-	-
MKNK2 (Q9HBH9)	Homo sapiens	S294	TSVSAVASNMRDDEI	0.615	0.7547	-	-	-	-	-	-	-
MKNK2 (Q9HBH9)	Homo sapiens	S250	PNNNNMPSSDDGLEH	0.816	0.6576	-	-	-	-	-	-	-
MKNK2 (Q9HBH9)	Homo sapiens	S251	NNNNMPSSDDGLEHN	0.679	0.7629	-	-	-	-	-	-	-
MKNK2 (Q9HBH9)	Homo sapiens	S309	TQDENTVSTSLGHSK	0.402	0.7982	-	-	-	-	-	-	-
MKNK2 (Q9HBH9)	Homo sapiens	S282	VQGEEKESSNDSTSV	0.604	0.6906	-	-	-	-	-	-	-
MKNK2 (Q9HBH9)	Homo sapiens	S311	DENTVSTSLGHSKDE	0.34	0.7755	-	-	-	-	-	-	-
MKNK2 (Q9HBH9)	Homo sapiens	T302	NMRDDEITQDENTVS	0.144	0.7036	-	-	-	-	-	-	-
MKNK2 (Q9HBH9)	Homo sapiens	T287	KESSNDSTSVSAVAS	0.994	0.8013	-	-	-	-	-	-	-
MKNK2 (Q9HBH9)	Homo sapiens	T271	KAPRDPVTENCVQGE	0.152	0.8013	-	-	-	-	-	-	-
MKNK2 (Q9HBH9)	Homo sapiens	T307	EITQDENTVSTSLGH	0.173	0.7982	-	-	-	-	-	-	-
MKNK2 (Q9HBH9)	Homo sapiens	T310	QDENTVSTSLGHSKD	0.374	0.7916	-	-	-	-	-	-	-

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

No KEGG pathways found

No NCI Nature pathways found