CaMKipedia | Result

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Sequence Viewer

Gene

MKNK2

Synonyms

GPRK7 MNK2

Protein Name

MAP kinase-interacting serine/threonine-protein kinase 2

UniProt ID

Q9HBH9

Ensembl Gene ID

9606.ENSP00000250896

NCBI Gene ID

2872

Molecular Weight

51,875

Protein Length

465

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 6ck3)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

2.7.11.1 (BRENDA)

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

ATP + a protein = ADP + a phosphoprotein.

Localization

Isoform 2: Nucleus, PML body.; Isoform 1: Cytoplasm.

Function

Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Isoform 1 displays a high basal kinase activity, but isoform 2 exhibits a very low kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal.

Gene Ontology

GO:0004674; GO:0004683; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0006417; GO:0006468; GO:0007166; GO:0009931; GO:0016604; GO:0016605; GO:0018105; GO:0030097; GO:0035556; GO:0046872; GO:0071243; GO:0097192

Gene Ontology

Substrate	Organism	PSite	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
SPRY2 (O43597)	Homo sapiens	S112	APLSRSISTVSSGSR	0.354	0.712	TP	certain	experimental	140 \| 148 \| 8 \|	19864419	-	In vivo
SPRY2 (O43597)	Homo sapiens	S121	VSSGSRSSTRTSTSS	0.854	0.7369	TP	certain	experimental	140 \| 148 \| 8 \|	19864419	-	In vivo
SFPQ (P23246)	Homo sapiens	S8	MSRDRFRSRGGGGGG	0.448	0.9916	TP	certain	experimental	72 \| 107 \| 30 \| 9 \| 55 \| 148 \|	17965020	-	-
SFPQ (P23246)	Homo sapiens	S283	EGFKANLSLLRRPGE	0.784	0.6851	TP	certain	experimental	72 \| 107 \| 30 \| 9 \| 148 \|	17965020	-	-
PLEC (Q15149)	Homo sapiens	S4642	RAGSRRGSFDATGSG	0.689	0.5211	TP	certain	experimental	148 \| 55 \|	23843618	-	-
EIF4E * (P06730)	Homo sapiens	S209	DTATKSGSTTKNRFV	0.815	0.4582	TP	certain	experimental	72 \| 137 \| 133 \| 147 \| 73 \|	11154262	-	-
HNRNPA1 (P09651)	Homo sapiens	S192	EMASASSSQRGRSGS	0.141	0.7331	-	-	-	-	-	-	-
HNRNPA1 (P09651)	Homo sapiens	S362	GGYGGSSSSSSYGSG	0.119	0.6375	-	-	-	-	-	-	-
HNRNPA1 (P09651)	Homo sapiens	S363	GYGGSSSSSSYGSGR	0.046	0.6043	-	-	-	-	-	-	-
ADRB2 (P07550)	Homo sapiens	S355	KAYGNGYSSNGNTGE	0.53	0.4652	-	-	-	-	-	-	-
ADRB2 (P07550)	Homo sapiens	S356	AYGNGYSSNGNTGEQ	0.173	0.384	-	-	-	-	-	-	-
CHRM2 (P08172)	Homo sapiens	S286	EKESSNDSTSVSAVA	0.892	0.805	-	-	-	-	-	-	-
CHRM2 (P08172)	Homo sapiens	S288	ESSNDSTSVSAVASN	0.99	0.8125	-	-	-	-	-	-	-
CHRM2 (P08172)	Homo sapiens	S283	QGEEKESSNDSTSVS	0.516	0.6576	-	-	-	-	-	-	-
CHRM2 (P08172)	Homo sapiens	S234	NQDPVSPSLVQGRIV	0.936	0.5254	-	-	-	-	-	-	-
CHRM2 (P08172)	Homo sapiens	S290	SNDSTSVSAVASNMR	0.99	0.805	-	-	-	-	-	-	-
CHRM2 (P08172)	Homo sapiens	S232	VANQDPVSPSLVQGR	0.709	0.4979	-	-	-	-	-	-	-
CHRM2 (P08172)	Homo sapiens	S294	TSVSAVASNMRDDEI	0.615	0.7547	-	-	-	-	-	-	-
CHRM2 (P08172)	Homo sapiens	S250	PNNNNMPSSDDGLEH	0.816	0.6576	-	-	-	-	-	-	-
CHRM2 (P08172)	Homo sapiens	S251	NNNNMPSSDDGLEHN	0.679	0.7629	-	-	-	-	-	-	-
CHRM2 (P08172)	Homo sapiens	S309	TQDENTVSTSLGHSK	0.402	0.7982	-	-	-	-	-	-	-
CHRM2 (P08172)	Homo sapiens	S282	VQGEEKESSNDSTSV	0.604	0.6906	-	-	-	-	-	-	-
CHRM2 (P08172)	Homo sapiens	S311	DENTVSTSLGHSKDE	0.34	0.7755	-	-	-	-	-	-	-
MC4R (P32245)	Homo sapiens	S329	LGGLCDLSSRY____	0.124	0.0044	-	-	-	-	-	-	-
MC4R (P32245)	Homo sapiens	S330	GGLCDLSSRY_____	0.093	0.006	-	-	-	-	-	-	-
CCR5 (P51681)	Homo sapiens	S336	QEAPERASSVYTRST	0.802	0.2817	-	-	-	-	-	-	-
CCR5 (P51681)	Homo sapiens	S337	EAPERASSVYTRSTG	0.974	0.3872	-	-	-	-	-	-	-
CCR5 (P51681)	Homo sapiens	S349	STGEQEISVGL____	0.726	0.2094	-	-	-	-	-	-	-
CCR5 (P51681)	Homo sapiens	S342	ASSVYTRSTGEQEIS	0.835	0.2752	-	-	-	-	-	-	-
ADRB2 (P07550)	Homo sapiens	S411	RNCSTNDSLL_____	0.56	0.3948	-	-	-	-	-	-	-
ADRB2 (P07550)	Homo sapiens	S364	NGNTGEQSGYHVEQE	0.174	0.5951	-	-	-	-	-	-	-
ADRB2 (P07550)	Homo sapiens	S401	VPSDNIDSQGRNCST	0.543	0.6136	-	-	-	-	-	-	-
ADRB2 (P07550)	Homo sapiens	S407	DSQGRNCSTNDSLL_	0.721	0.4256	-	-	-	-	-	-	-
ADRA1B (P35368)	Homo sapiens	S410	RKDSLDDSGSCLSGS	0.859	0.5707	-	-	-	-	-	-	-
ADRA1B (P35368)	Homo sapiens	S412	DSLDDSGSCLSGSQR	0.573	0.5139	-	-	-	-	-	-	-
ADRA1B (P35368)	Homo sapiens	S406	RSQSRKDSLDDSGSC	0.847	0.4619	-	-	-	-	-	-	-
CHRM2 (P08172)	Homo sapiens	T302	NMRDDEITQDENTVS	0.144	0.7036	-	-	-	-	-	-	-
CHRM2 (P08172)	Homo sapiens	T287	KESSNDSTSVSAVAS	0.994	0.8013	-	-	-	-	-	-	-
CHRM2 (P08172)	Homo sapiens	T271	KAPRDPVTENCVQGE	0.152	0.8013	-	-	-	-	-	-	-
CHRM2 (P08172)	Homo sapiens	T307	EITQDENTVSTSLGH	0.173	0.7982	-	-	-	-	-	-	-
CHRM2 (P08172)	Homo sapiens	T310	QDENTVSTSLGHSKD	0.374	0.7916	-	-	-	-	-	-	-
MC4R (P32245)	Homo sapiens	T312	RSQELRKTFKEIICC	0.809	0.0059	-	-	-	-	-	-	-
ADRB2 (P07550)	Homo sapiens	T384	LCEDLPGTEDFVGHQ	0.302	0.2328	-	-	-	-	-	-	-
ADRB2 (P07550)	Homo sapiens	T408	SQGRNCSTNDSLL__	0.612	0.3872	-	-	-	-	-	-	-

Kinase

Substrate

Interactor

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system TAS \| Reactome Pathway
R-HSA-168256	Immune System TAS \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins TAS \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling TAS \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
hsa04010	MAPK signaling pathway
hsa04910	Insulin signaling pathway

No NCI Nature pathways found