| Gene |
ALOX5
|
| Protein Name |
LOX5_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Arachidonate 5-lipoxygenase (5-LO) (5-lipoxygenase) (EC 1.13.11.34) |
| Protein Family |
Lipoxygenase family |
| NCBI Gene ID |
240
|
| UniProt ID |
P09917
|
| Enzyme Class |
1.13.11.34 |
| Molecular Weight |
77983 |
| Protein Length |
674 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
Arachidonate + O(2) = leukotriene A(4) + H(2)O. |
| Localization |
Cytoplasm. Nucleus matrix. Nucleus membrane; Peripheral membrane protein. Note=Shuttles between cytoplasm and nucleus. Found exclusively in the nucleus, when phosphorylated on Ser-272. Calcium binding promotes translocation from the cytosol and the nuclear matrix to the nuclear envelope and membrane association. |
| Function (UniProt annotation) |
Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes. |
| Gene Ontology |
GO:0002540; GO:0004051; GO:0005506; GO:0005576; GO:0005615; GO:0005635; GO:0005641; GO:0005654; GO:0005829; GO:0006691; GO:0016363; GO:0019221; GO:0019370; GO:0019372; GO:0031965; GO:0034774; GO:0035655; GO:0042759; GO:0043312; GO:1904813 |
