| Gene |
Parp1
|
| Protein Name |
PARP1_MOUSE |
| Organism |
Mus musculus (Mouse) |
| Alternative name(s) |
Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (msPARP) |
| Protein Family |
N/A |
| NCBI Gene ID |
N/A
|
| UniProt ID |
P11103
|
| Enzyme Class |
2.4.2.30 |
| Molecular Weight |
113100 |
| Protein Length |
1013 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor. |
| Localization |
Nucleus |
| Function (UniProt annotation) |
Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Required for PARP9 and DTX3L recruitment to DNA damage sites. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites. Mediates serine ADP-ribosylation of target proteins following interaction with HPF1; HPF1 conferring serine specificity. Mediates the poly(ADP-ribosyl)ation of histones in a HPF1-dependent manner. Involved in the synthesis of ATP in the nucleus, together with NMNAT1, PARG and NUDT5. Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming. |
| Gene Ontology |
GO:0000723; GO:0000977; GO:0001228; GO:0003682; GO:0003950; GO:0005634; GO:0005635; GO:0005654; GO:0005667; GO:0005730; GO:0005737; GO:0005739; GO:0006259; GO:0006281; GO:0006284; GO:0006302; GO:0006471; GO:0006915; GO:0006974; GO:0007005; GO:0007179; GO:0008134; GO:0008270; GO:0010613; GO:0010990; GO:0016540; GO:0018312; GO:0019899; GO:0019901; GO:0023019; GO:0030331; GO:0032042; GO:0032869; GO:0032991; GO:0032993; GO:0033148; GO:0034599; GO:0034644; GO:0036211; GO:0040009; GO:0042769; GO:0042802; GO:0042826; GO:0043504; GO:0044030; GO:0045944; GO:0046332; GO:0047485; GO:0048148; GO:0050790; GO:0050882; GO:0051287; GO:0051901; GO:0060391; GO:0070212; GO:0070412; GO:0071451; GO:0071560; GO:0090734; GO:1900182; GO:1901216; GO:1903376; GO:1903516; GO:1903518; GO:1903827; GO:1904357; GO:1904646; GO:1904762; GO:1905077; GO:1990404; GO:1990966; GO:2000679; GO:2001170 |
