CaMKinet | Result

Sequence Viewer

Parameter	Value
Gene	Camk2a
Protein Name	KCC2A_RAT
Organism	Rattus norvegicus (Rat)
Alternative name(s)	Calcium/calmodulin-dependent protein kinase type II subunit alpha (CaM kinase II subunit alpha) (CaMK-II subunit alpha) (EC 2.7.11.17)
Protein Family	Protein kinase superfamily
NCBI Gene ID	25400
UniProt ID	P11275
Enzyme Class	2.7.11.17
Molecular Weight	54115
Protein Length	478
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	ATP + a protein = ADP + a phosphoprotein.
Localization	Cell junction, synapse
Function (UniProt annotation)	Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in synaptic plasticity, neurotransmitter release and long-term potentiation. Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (PubMed:15312654). Regulates dendritic spine development. Also regulates the migration of developing neurons. Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (By similarity).
Gene Ontology	GO:0000082; GO:0002931; GO:0004674; GO:0004683; GO:0005516; GO:0005524; GO:0005634; GO:0005737; GO:0005739; GO:0005829; GO:0005954; GO:0006468; GO:0006816; GO:0010666; GO:0014069; GO:0016020; GO:0018105; GO:0030054; GO:0030424; GO:0030425; GO:0032794; GO:0032839; GO:0035235; GO:0035254; GO:0043005; GO:0043025; GO:0043197; GO:0046777; GO:0046872; GO:0046928; GO:0048168; GO:0051928; GO:0060996; GO:0098696; GO:0098970; GO:0098978; GO:0098989; GO:0099004; GO:0099523; GO:0099524; GO:0099573; GO:0099634; GO:1902108; GO:1903076; GO:1990443; GO:2001222

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
CAMK2A (Q9UQM7)	Homo sapiens	S314	MLATRNFSGGKSGGN	N/A	0.5211	-	-	-	-	-	-	In vitro
CAMK2A (Q9UQM7)	Homo sapiens	T305	KLKGAILTTMLATRN	N/A	0.2951	-	-	-	-	-	-	In vitro
CAMK2A (Q9UQM7)	Homo sapiens	T306	LKGAILTTMLATRNF	N/A	0.3182	-	-	-	-	-	-	In vitro
CAMK2A (Q9UQM7)	Homo sapiens	T310	ILTTMLATRNFSGGK	N/A	0.4017	-	-	-	-	-	-	In vitro

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
rno04012	ErbB signaling pathway
rno04020	Calcium signaling pathway
rno04114	Oocyte meiosis
rno04310	Wnt signaling pathway
rno04720	Long-term potentiation
rno04722	Neurotrophin signaling pathway
rno04725	Cholinergic synapse
rno04740	Olfactory transduction
rno04912	GnRH signaling pathway
rno04916	Melanogenesis
rno04971	Gastric acid secretion
rno05152	Tuberculosis
rno05214	Glioma

No NCI Nature pathways found