CaMKinet | Result

Sequence Viewer

Parameter	Value
Gene	Mylk
Protein Name	MYLK_CHICK
Organism	Gallus gallus (Chicken)
Alternative name(s)	Myosin light chain kinase, smooth muscle (MLCK) (EC 2.7.11.18) (Telokin) [Cleaved into: Myosin light chain kinase, smooth muscle, deglutamylated form]
Protein Family	Protein kinase superfamily
NCBI Gene ID	N/A
UniProt ID	P11799
Enzyme Class	2.7.11.18
Molecular Weight	210446
Protein Length	1906
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	ATP + [myosin light-chain] = ADP + [myosin light-chain] phosphate.
Localization	Cytoplasm, cytosol Note=Telokin is cytosolic and can translocate to the membrane upon stimulation.
Function (UniProt annotation)	Phosphorylates a specific serine in the N-terminus of a myosin light chain, which leads to the formation of calmodulin/MLCK signal transduction complexes which allow selective transduction of calcium signals.
Gene Ontology	GO:0004687; GO:0005516; GO:0005524; GO:0005829; GO:0005865; GO:0006936; GO:0008307; GO:0016020; GO:0030017; GO:0030018; GO:0030240; GO:0030241; GO:0031430; GO:0045214; GO:0046872; GO:0048739; GO:0051015; GO:0051371; GO:0055003; GO:0055008

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
PRKAA1 (Q13131)	Homo sapiens	S1749	RAIGRLSSMAMISGM	N/A	0.3774	TP	certain	experimental	73 \| 31 \|	18426792	-	In vitro
CAMK2A (Q9UQM7)	Homo sapiens	S1749	RAIGRLSSMAMISGM	N/A	0.3774	-	-	-	-	-	-	In vitro
CAMK2A (Q9UQM7)	Homo sapiens	S1762	GMSGRKASGSSPTSP	N/A	0.6227	-	-	-	-	-	-	In vitro

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
gga04020	Calcium signaling pathway
gga04270	Vascular smooth muscle contraction
gga04510	Focal adhesion
gga04810	Regulation of actin cytoskeleton

No NCI Nature pathways found